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Prognostic factors in patients with metastatic spinal cord compression secondary to lung cancer-A retrospective UK single-centre study

Vassiliou, Anna, Osunronbi, Temidayo, Enyioma, Synthia, Rago, Gerardo, Karathanasi, Afroditi, Ghose, Aruni, Sheriff, Matin, Mikropoulos, Christos, Sanchez, Elisabet, Moschetta, Michele, and others. (2023) Prognostic factors in patients with metastatic spinal cord compression secondary to lung cancer-A retrospective UK single-centre study. Cancers, 15 (18). Article Number 4432. ISSN 2072-6694. (doi:10.3390/cancers15184432) (KAR id:103156)


PurposeMetastatic spinal cord compression (MSCC) is a severe complication of cancer that can lead to irreversible neurological impairment, necessitating prompt recognition and intervention. This retrospective, single-centre study aimed to determine the prognostic factors and survival rates among patients presenting with MSCC secondary to lung cancer.Methods and materialsWe identified 74 patients with epidural metastases-related spinal cord compression and a history of lung cancer through the electronic database of Medway Maritime Hospital in the United Kingdom (UK), spanning the period from April 2016 to September 2021. Among them, 39 were below 55 years old, while 35 were aged 55 years or older; 24 patients were diagnosed with small cell lung cancer (SCLC), and 50 patients had non-small cell lung cancer (NSCLC).ResultsThe median overall survival (OS) was 5.5 months, with 52 out of 74 patients dying within 6 months of diagnosis with MSCC. For the entire cohort, the statistically significant variables on multi-variate analysis were cancer type (NSCLC had improved OS), the number of involved vertebrae (one to two vertebrae involvement had improved OS), and the time taken to develop motor deficits (≤10 days to develop motor deficits had worsened OS). For the NSCLC cohort, the statistically significant variables on multivariate analysis were molecular alterations (patients with epidermal growth factor receptor (EGFR) mutation), pre-treatment ambulatory status, Eastern Cooperative Oncology Group (ECOG) performance status, and the time taken to develop motor deficits.ConclusionsWithin the entire cohort, patients diagnosed with NSCLC and spinal metastases affecting one to two vertebrae exhibited enhanced OS. Within the NSCLC subgroup, those with EGFR mutations who were ambulatory and possessed an ECOG performance status of 1-2 demonstrated improved OS. In both the entire cohort and the NSCLC subgroup, the development of motor deficits within a period of ≤10 days was associated with poor OS.

Item Type: Article
DOI/Identification number: 10.3390/cancers15184432
Uncontrolled keywords: metastatic spinal cord compression; lung cancer; survivor; prognostic factors
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 20 Oct 2023 11:04 UTC
Last Modified: 11 Jan 2024 00:07 UTC
Resource URI: (The current URI for this page, for reference purposes)

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