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Exosomes in the diagnosis and treatment of renal cell cancer

Boussios, Stergios, Devo, Perry, Goodall, Iain C A, Sirlantzis, Konstantinos, Ghose, Aruni, Shinde, Sayali D, Papadopoulos, Vasileios, Sanchez, Elisabet, Rassy, Elie, Ovsepian, Saak V and others. (2023) Exosomes in the diagnosis and treatment of renal cell cancer. International Journal of Molecular Sciences, 24 (18). Article Number 14356. ISSN 1661-6596. E-ISSN 1422-0067. (doi:10.3390/ijms241814356) (KAR id:103155)


Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer originating from renal tubular epithelial cells, with clear cell RCC comprising approximately 80% of cases. The primary treatment modalities for RCC are surgery and targeted therapy, albeit with suboptimal efficacies. Despite progress in RCC research, significant challenges persist, including advanced distant metastasis, delayed diagnosis, and drug resistance. Growing evidence suggests that extracellular vesicles (EVs) play a pivotal role in multiple aspects of RCC, including tumorigenesis, metastasis, immune evasion, and drug response. These membrane-bound vesicles are released into the extracellular environment by nearly all cell types and are capable of transferring various bioactive molecules, including RNA, DNA, proteins, and lipids, aiding intercellular communication. The molecular cargo carried by EVs renders them an attractive resource for biomarker identification, while their multifarious role in the RCC offers opportunities for diagnosis and targeted interventions, including EV-based therapies. As the most versatile type of EVs, exosomes have attracted much attention as nanocarriers of biologicals, with multi-range signaling effects. Despite the growing interest in exosomes, there is currently no widely accepted consensus on their subtypes and properties. The emerging heterogeneity of exosomes presents both methodological challenges and exciting opportunities for diagnostic and clinical interventions. This article reviews the characteristics and functions of exosomes, with a particular reference to the recent advances in their application to the diagnosis and treatment of RCC.

Item Type: Article
DOI/Identification number: 10.3390/ijms241814356
Uncontrolled keywords: mRNA, miRNA; Renal cell cancer; Tumor Microenvironment; Exosomes; Tumor Drug Resistance
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 13 Oct 2023 13:21 UTC
Last Modified: 15 Jan 2024 22:30 UTC
Resource URI: (The current URI for this page, for reference purposes)

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