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Tools to enable the study and translation of supramolecular amphiphiles

Allam, Thomas, Balderston, Dominick, Chahal, Mandeep, Hilton, Kira L.F., Hind, Charlie, Keers, Olivia, Lilley, Rebecca, Manwani, Chandni, Overton, Alix, Popoola, Precious, and others. (2023) Tools to enable the study and translation of supramolecular amphiphiles. Chemical Society Reviews, . Article Number D3CS00480E. ISSN 0306-0012. E-ISSN 1460-4744. (doi:10.1039/D3CS00480E) (KAR id:102628)

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This tutorial review focuses on providing a summary of the key techniques used for the characterisation of supramolecular amphiphiles and their self-assembled aggregates; from the understanding of low-level molecular interactions, to materials analysis, use of data to support computer-aided molecular design and finally, the translation of this class of compounds for real world application, specifically within the clinical setting. We highlight the common methodologies used for the study of traditional amphiphiles and build to provide specific examples that enable the study of specialist supramolecular systems. This includes the use of nuclear magnetic resonance spectroscopy, mass spectrometry, x-ray scattering techniques (small- and wide-angle x-ray scattering and single crystal x-ray diffraction), critical aggregation (or micelle) concentration determination methodologies, machine learning, and various microscopy techniques. Furthermore, this review provides guidance for working with supramolecular amphiphiles in in vitro and in vivo settings, as well as the use of accessible software programs, to facilitate screening and selection of druggable molecules. Each section provides: a methodology overview – information that may be derived from the use of the methodology described; a case study – examples for the application of these methodologies; and a summary section – providing methodology specific benefits, limitations and future applications.

Item Type: Article
DOI/Identification number: 10.1039/D3CS00480E
Additional information: For the purpose of open access, the author(s) has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising.
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders: UK Research and Innovation (
Biotechnology and Biological Sciences Research Council (
University of Kent (
Depositing User: Jennifer Hiscock
Date Deposited: 31 Aug 2023 09:20 UTC
Last Modified: 03 May 2024 03:16 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Balderston, Dominick.

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Chahal, Mandeep.

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Keers, Olivia.

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Lilley, Rebecca.

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Hiscock, Jennifer R..

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