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Capture and inactivation of viral particles from bioaerosols by electrostatic precipitation.

Preston, Hannah E., Bayliss, Rebecca, Temperton, Nigel, Neto, Martin Mayora, Brewer, Jason, Parker, Alan L. (2023) Capture and inactivation of viral particles from bioaerosols by electrostatic precipitation. iScience, 26 (9). Article Number 107567. ISSN 2589-0042. (doi:10.1016/j.isci.2023.107567) (KAR id:102424)

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Official URL:
https://doi.org/10.1016/j.isci.2023.107567

Abstract

Infectious viral particles in bioaerosols generated during laparoscopic surgery place staff and patients at significant risk of infection and contributed to the postponement of countless surgical procedures during the COVID-19 pandemic causing excess deaths. The implementation of devices that inactivate viral particles from bioaerosols aid in preventing nosocomial viral spread. We evaluated whether electrostatic precipitation (EP) is effective in capturing and inactivating aerosolised enveloped and non-enveloped viruses. Using a closed-system model mimicking release of bioaerosols during laparoscopic surgery, known concentrations of each virus were aerosolised, exposed to EP and collected for analysis. We demonstrate that both enveloped and non-enveloped viral particles were efficiently captured and inactivated by EP, which was enhanced by increasing the voltage to 10kV or using two discharge electrodes together at 8kV. This study highlights EP as an effective means for capturing and inactivating viral particles in bioaerosols, which may enable continued surgical procedures during future pandemics.

Item Type: Article
DOI/Identification number: 10.1016/j.isci.2023.107567
Additional information: For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Uncontrolled keywords: Virology, Particle Technology
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Funders: Wellcome Trust (https://ror.org/029chgv08)
Depositing User: Nigel Temperton
Date Deposited: 12 Aug 2023 21:52 UTC
Last Modified: 04 Oct 2023 14:42 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/102424 (The current URI for this page, for reference purposes)
Temperton, Nigel: https://orcid.org/0000-0002-7978-3815
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