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Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study

Chau, Yau-Lam Alex, Yoo, Ji Won, Zhou, Jiandong, LiutaoGuo, Cosmos, Wong, Wing Tak, Chang, Carlin, Liu, Tong, Jeevaratnam, Kamalan, Zhang, Qingpeng, Tse, Gary, and others. (2023) Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study. Aging and Health Research, 3 (3). Article Number 100155. ISSN 2667-0321. (doi:10.1016/j.ahr.2023.100155) (KAR id:102394)


This population-based cohort study investigated the risk factors of incident dementia and vascular dementia in type 2 diabetic patients (≥45 years old) attending the Hong Kong Hospital Authority between 1st January and 31st December 2009.Of the 273,876 patients included,9994 showed incident dementia (median follow-up: 4245 days). Multivariable Cox regression identified older age (HR: 1.09 [95% CI: 1.08–1.10]) and antiplatelet use (HR: 1.36 [1.14–1.62]) as risk factors for incident dementia, and older age (HR: 1.07 [1.06–1.08]), ischemic stroke (HR: 1.47 [1.09–1.98]), fasting blood glucose (HR: 1.10 [1.01–1.20]), antiplatelets (HR: 1.92 [1.51–2.44]), and calcium channel blocker (HR: 1.28 [1.04–1.57]) use as risk factors of incident vascular dementia.

Item Type: Article
DOI/Identification number: 10.1016/j.ahr.2023.100155
Uncontrolled keywords: dementia; type 2 diabetes; vascular; risk factors
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 15 Aug 2023 10:38 UTC
Last Modified: 11 Jan 2024 18:02 UTC
Resource URI: (The current URI for this page, for reference purposes)

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