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Supramolecular self-assembly of engineered polyproline helices

Brightwell, Dominic F., Truccolo, Giada, Samanta, Kushal, Shepherd, Helena J., Palma, Aniello (2023) Supramolecular self-assembly of engineered polyproline helices. ACS Macro Letters, 12 (7). pp. 908-914. E-ISSN 2161-1653. (doi:10.1021/acsmacrolett.3c00304) (KAR id:102229)

Abstract

The ability to rationally design biomaterials to form desired supramolecular constructs presents an ever-growing research field, with many burgeoning works within recent years providing exciting results; however, there exists a broad expanse of promising avenues of research yet to be investigated. As such we have set out to make use of the polyproline helix as a rigid, tunable, and chiral ligand for the rational design and synthesis of supramolecular constructs. In this investigation, we show how an oligoproline tetramer can be specifically designed and functionalized, allowing predictable tuning of supramolecular interactions, to engineer the formation of supramolecular peptide frameworks with varying properties and, consequently, laying the groundwork for further studies utilizing the polyproline helix, with the ability to design desired supramolecular structures containing these peptide building blocks, having tunable structural features and functionalities.

Item Type: Article
DOI/Identification number: 10.1021/acsmacrolett.3c00304
Additional information: For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Uncontrolled keywords: Materials Chemistry; Inorganic Chemistry; Polymers and Plastics; Organic Chemistry
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Funders: Engineering and Physical Sciences Research Council (https://ror.org/0439y7842)
Royal Society of Chemistry (https://ror.org/025sbr097)
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 04 Aug 2023 11:21 UTC
Last Modified: 07 Aug 2023 10:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/102229 (The current URI for this page, for reference purposes)

University of Kent Author Information

Brightwell, Dominic F..

Creator's ORCID: https://orcid.org/0000-0001-7699-9795
CReDIT Contributor Roles:

Truccolo, Giada.

Creator's ORCID:
CReDIT Contributor Roles:

Samanta, Kushal.

Creator's ORCID: https://orcid.org/0000-0002-7414-4475
CReDIT Contributor Roles:

Shepherd, Helena J..

Creator's ORCID: https://orcid.org/0000-0003-0832-4475
CReDIT Contributor Roles:

Palma, Aniello.

Creator's ORCID: https://orcid.org/0000-0001-9626-4390
CReDIT Contributor Roles:
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