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Advances in Adoptive T-cell Therapy for Metastatic Melanoma

Das, Aparimita, Ghose, Aruni, Naicker, Kevin, Sanchez, Elisabet, Chargari, Cyrus, Rassy, Elie, Boussios, Stergios (2023) Advances in Adoptive T-cell Therapy for Metastatic Melanoma. Current Research in Translational Medicine, 71 (3). Article Number 103404. ISSN 2452-3186. (doi:10.1016/j.retram.2023.103404) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:102004)

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Official URL:
https://doi.org/10.1016/j.retram.2023.103404

Abstract

Adoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic melanoma (MM). Identifying tumour antigens (TAs) as potential targets, the ACT response is mediated by either Tumour Infiltrating Lymphocytes (TILs) or genetically modified T cells with specific receptors – T cell receptors (TCRs) or Chimeric antigen receptors (CARs) or more prospectively, natural killer (NK) cells. Clinical trials involving ACT in MM from 2006 to present have shown promising results. Yet it is not without its drawbacks which include significant auto-immune toxicity and need for pre-conditioning lymphodepletion. Although immune-modulation is underway using various combination therapies in the hope of enhancing efficacy and reducing toxicity. Our review article explores the role of ACT in MM, including the various modalities – their safety, efficacy, risks and their development in the trial and the real world setting.

Item Type: Article
DOI/Identification number: 10.1016/j.retram.2023.103404
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (https://ror.org/00xkeyj56)
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 11 Jul 2023 13:43 UTC
Last Modified: 07 Sep 2023 10:30 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/102004 (The current URI for this page, for reference purposes)

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