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Predictors of ventricular arrhythmias in patients with Mitral valve prolapse: A meta-analysis.

Bazoukis, George, Saplaouras, Athanasios, Vlachos, Konstantinos, Mililis, Panagiotis, Letsas, Konstantinos P, Efremidis, Michael, Liu, Tong, Tse, Gary (2023) Predictors of ventricular arrhythmias in patients with Mitral valve prolapse: A meta-analysis. Cardiology in review, . ISSN 1061-5377. E-ISSN 1538-4683. (doi:10.1097/CRD.0000000000000577) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:101919)

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Official URL:
https://doi.org/10.1097/CRD.0000000000000577

Abstract

Mitral valve prolapse (MVP) has an estimated prevalence of 2-3% in the general population. Patients with MVP have an increased risk of ventricular arrhythmic events. The aim of this meta-analysis was to identify easily obtained markers that can be used for the arrhythmic risk stratification of MVP patients. This meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA Statement). The search strategy identified 23 studies that were finally included in the study. The quantitative synthesis showed that late gadolinium enhancement (LGE) [RR 6.40 (2.11-19.39), I2 77%, P = 0.001], longer QTc interval [mean difference: 14.2 (8.92-19.49) I2 0%, P < 0.001], T-wave inversion in inferior leads [RR 1.60 (1.39-1.86), I2 0%, P < 0.001], mitral annular disjunction (MAD) [RR 1.77 (1.29-2.44), I2 37%, P = 0.0005], lower left ventricular ejection fraction (LVEF) [mean difference: -0.77 (-1.48, -0.07) I2 0%, P = 0.03], bileaflet MVP [RR 1.32 (1.16-1.49), I2 0%, P < 0.001], increased anterior [mean difference: 0.45 (0.28, 0.61), I2 0%, P < 0.001] and posterior [mean difference: 0.39 (0.26, 0.52), I2 0%, P < 0.001] mitral leaflet thickness were significantly associated with ventricular arrhythmias in MVP patients. On the other hand, gender, QRS duration, anterior, and posterior mitral leaflet length were not associated with increased risk of arrhythmias. In conclusion, inferior T-wave inversions, QTc interval, LGE, LVEF, MAD, bileaflet MVP, anterior, and posterior mitral leaflet thickness are easily obtained markers that can be used for the risk stratification of patients with MVP. Prospective studies should be designed for the better stratification of this population. [Abstract copyright: Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.]

Item Type: Article
DOI/Identification number: 10.1097/CRD.0000000000000577
Uncontrolled keywords: mitral valve prolapse; ventricular arrhythmias; sudden cardiac death; risk stratification
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 11 Aug 2023 13:57 UTC
Last Modified: 14 Aug 2023 15:31 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/101919 (The current URI for this page, for reference purposes)

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