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Investigation into alternative sugars as potential carriers for dry powder formulation of budesonide

Momin, Mohammed-Nural, Nokhodchi, Ali, Hedayati, Atoosa (2011) Investigation into alternative sugars as potential carriers for dry powder formulation of budesonide. Bioimpacts, 1 (2). pp. 105-111. E-ISSN 2228-5660. (doi:10.5681/bi.2011.014) (KAR id:101836)


Introduction: Dry powder inhaler (DPI) formulations are so far being used for pulmonary drug delivery, mainly for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Currently most of DPI formulations rely on lactose as a carrier in the drug powder blend. However, due to reducing sugar function of lactose which makes it incompatible with some drugs such as budesonide, it is realistic to investigate for alternative sugars that would overcome the concerned drawback but still have the positive aspects of lactose.

Methods: The study was conducted by characterizing carriers for their physico-chemical properties and preparing drug/carrier blends with concentration of 5% and 10% drug with the carrier. The mixing uniformity (homogeneity) of Budesonide in the blends was analyzed using spectrophotometer. The blend was then filled into NB7/2 Airmax inhaler device and the deposition profiles of the drug were determined using multi stage liquid impinger (MSLI) after aerosolization at 4 kPa via the inhaler. The morphology of the carriers conducted using the scanning electron microscope.

Results: The results determined that the mean fine particle fraction (FPF) of 5% and 10% blends of mannitol was 61%, possibly due to fine elongated particles. Dextrose exhibited excellent flowability. Scanning electron microscope illustrated mannitol with fine elongated particles and dextrose presenting larger and coarse particles. It was found out that type of carriers, particle size distribution, and morphology would influence the FPF of budesonide.

Conclusion: It may be concluded that mannitol could be suitable as a carrier on the basis of its pharmaceutical performance and successful achievement of FPF whereas the more hygroscopic sugars such as sorbitol or xylitol showed poor dispersibility leading to lower FPF.

Item Type: Article
DOI/Identification number: 10.5681/bi.2011.014
Projects: Sustained Research Project
Uncontrolled keywords: Dry powder inhaler; budesonide; physico-chemical properties; fine particle dose; fine particle fraction
Subjects: R Medicine > R Medicine (General)
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Funders: University of Kent (
Depositing User: Mohammed Momin
Date Deposited: 26 Jun 2023 13:15 UTC
Last Modified: 27 Jun 2023 10:34 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Momin, Mohammed-Nural.

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Nokhodchi, Ali.

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