Skip to main content
Kent Academic Repository

Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses

Fereidouni, Sasan, Starick, Elke, Karamendin, Kobey, Di Genova, Cecilia, Scott, Simon D., Khan, Yelizaveta, Harder, Timm, Kydyrmanov, Aidyn (2023) Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses. Emerging Microbes & Infections, . E-ISSN 2222-1751. (doi:10.1080/22221751.2023.2225645) (KAR id:101756)


Avian influenza viruses (AIV) have been classified on the basis of 16 subtypes of hemagglutinin (HA) and 9 subtypes of neuraminidase. Here we describe genomic evidence for a new candidate HA subtype, nominally H19, with a large genetic distance to all previously described AIV subtypes, derived from a cloacal swab sample of a Common Pochard (Aythya ferina) in Kazakhstan, in 2008. Avian influenza monitoring in wild birds especially in migratory hotspots such as central Asia is an important approach to gain information about the circulation of known and novel influenza viruses. Genetically, the novel HA coding sequence exhibits only 68.2% nucleotide and 68.5% amino acid identity with its nearest relation in the H9 (N2) subtype. The new HA sequence should be considered in current genomic diagnostic AI assays to facilitate its detection and eventual isolation enabling further study and antigenic classification.

Item Type: Article
DOI/Identification number: 10.1080/22221751.2023.2225645
Uncontrolled keywords: Influenza A viruses, influenza subtypes, One-Health, Wild birds, Kazakhstan
Subjects: Q Science > QR Microbiology
Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Funders: University of Kent (
Depositing User: Simon Scott
Date Deposited: 20 Jun 2023 07:59 UTC
Last Modified: 21 Jun 2023 09:03 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.