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Preparation and characterization of solid dispersions of piroxicam with hydrophillic carriers

Valizadeh, Hadi, Zakeri, Parvin, Barzegar-Jalali, Mohammad, Mohammadi, Ghobad, Danesh- Bahreini, Mohammad- Ali, Adibkia, Khosro, Nokhodchi, Ali (2007) Preparation and characterization of solid dispersions of piroxicam with hydrophillic carriers. Drug Development and Industrial Pharmacy, 33 (1). pp. 45-56. ISSN 0363-9045. (doi:10.1080/03639040600814965) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:10169)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
http://dx.doi.org/10.1080/03639040600814965

Abstract

The objective of this study was to improve the dissolution rate of a poor water soluble drug, piroxicam, by solid dispersion technique. Solid dispersions were prepared by three different methods depending on the type of carrier. The dissolution rate of piroxicam was markedly increased in solid dispersion of myrj 52, Eudragit® E100 and mannitol. Solubility studies revealed a marked increase in the solubility of piroxicam with an increase in myrj 52 and Eudragit® E100 concentrations. Data from the X-ray diffraction and FT-IR spectroscopy showed that piroxicam was amorphous in the solid dispersions prepared with dextrin and Eudragit® E100.

Item Type: Article
DOI/Identification number: 10.1080/03639040600814965
Uncontrolled keywords: piroxicam; solid dispersion; coprecipitate; coevaporate; X-ray diffraction; FT-IR spectroscopy; dissolution
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Ali Nokhodchi
Date Deposited: 14 Jul 2008 09:29 UTC
Last Modified: 16 Nov 2021 09:48 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/10169 (The current URI for this page, for reference purposes)
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