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Semiparametric Trend Analysis for Stratified Recurrent Gap Times Under Weak Comparability Constraint

Liu, Peng, Huang, Yijian, Chan, Kwun Chuen Gary, Chen, Ying Qing (2023) Semiparametric Trend Analysis for Stratified Recurrent Gap Times Under Weak Comparability Constraint. Statistics in Biosciences, 15 (2). pp. 455-474. ISSN 1867-1772. (doi:10.1007/s12561-023-09376-8) (KAR id:101652)

Abstract

Recurrent event data are frequently encountered in many longitudinal studies where each individual may experience more than one event. Wang and Chen (Biometrics 56(3):789–794, 2000) proposed a comparability constraint to estimate the time trend for the gap times, where the gap time pairs that satisfy the constraint have the same conditional distribution. However, the comparable paired gap times are also independent. Therefore, the comparable gap time pairs will be subject to a stronger constraint than needed for the estimation. Thus their procedure is subject to information loss. Under the accelerated failure time model, we propose a new comparability constraint that can overcome the drawback mentioned above. The gap time pairs being selected by the proposed comparability constraint will still have the same distribution, but they do not need to be independent of each other. We showed that the proposed comparability constraint will utilize more gap time data pairs than the strong comparability. And we showed via various simulation studies that the variance will be smaller than Wang and Chen’s (2000) estimator. We apply the proposed method to the HIV Prevention Trial Network 052 study.

Item Type: Article
DOI/Identification number: 10.1007/s12561-023-09376-8
Uncontrolled keywords: Rank regression, gap time, recurrent event data, accelerated failure time model, comparability
Subjects: Q Science
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Mathematics, Statistics and Actuarial Science
Funders: University of Kent (https://ror.org/00xkeyj56)
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 20 Jul 2023 11:01 UTC
Last Modified: 21 Nov 2024 15:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/101652 (The current URI for this page, for reference purposes)

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