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Combination of SVI/S′ and diagnostic scores for heart failure with preserved ejection fraction

Mu, Guanyu, Wang, Weiding, Liu, Changle, Xie, Juan, Zhang, Hao, Zhang, Xiaowei, Che, Jingjin, Tse, Gary, Liu, Tong, Li, Guangping, and others. (2023) Combination of SVI/S′ and diagnostic scores for heart failure with preserved ejection fraction. Clinical and Experimental Pharmacology and Physiology, 50 (8). pp. 677-687. ISSN 1440-1681. (doi:10.1111/1440-1681.13782) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:101440)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL:
https://doi.org/10.1111/1440-1681.13782

Abstract

The diagnosis of heart failure with preserved ejection fraction (HFpEF) remains a challenge. There are three methods proposed as diagnostic tools. H2FPEF score was determined by six weighted clinical characteristics and echocardiographic variables. Heart Failure Association (HFA)-PEFF algorithm consists of various functional and morphological variables as well as natriuretic peptides. SVI/S′ is a novel echocardiographic parameter calculated by stroke volume index and mitral annulus systolic peak velocity. This study aimed to compare the three approaches in patients with suspected HFpEF. Patients referred to right heart catheterization for suspected HFpEF were classified into low-, intermediate- and high-likelihood groups according to H2FPEF or HFA-PEFF scores. A diagnosis of HFpEF was confirmed by pulmonary capillary wedge pressure (PCWP) of ≥15 mm Hg according to the guidelines. In result, a total of 128 patients were included. Of these, 71 patients with PCWP ≥15 mm Hg and 57 patients with PCWP <15 mm Hg. Moderate correlations were observed between H2FPEF score, HFA-PEFF score, SVI/S′ and PCWP. The area under curve of SVI/S′ was 0.82 for diagnosis of HFpEF, compared with 0.67 for H2FPEF score and 0.75 for HFA-PEFF score by receiver-operating characteristics analysis. Combining SVI/S′ with diagnostic scores showed higher Youden index and accuracy than each score alone. Kaplan–Meier analysis reported that the high-likelihood group showed poorer outcomes regardless the method used for diagnosis. Among the contemporary tools for identifying HFpEF in this study, the combination of SVI/S′ with risk scores showed best diagnostic ability. Each of the strategies can determine rehospitalisation because of heart failure.

Item Type: Article
DOI/Identification number: 10.1111/1440-1681.13782
Uncontrolled keywords: Physiology (medical), Pharmacology, Physiology
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 30 May 2023 14:03 UTC
Last Modified: 14 Jul 2023 13:44 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/101440 (The current URI for this page, for reference purposes)

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