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Association between sick sinus syndrome and atrial fibrillation: A systematic review and meta-analysis

Liu, Ying, Zheng, Yi, Tse, Gary, Bazoukis, George, Letsas, Konstantinos, Goudis, Christos, Korantzopoulos, Panagiotis, Li, Guangping, Liu, Tong (2023) Association between sick sinus syndrome and atrial fibrillation: A systematic review and meta-analysis. International Journal of Cardiology, . ISSN 0167-5273. (doi:10.1016/j.ijcard.2023.03.066) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:101004)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL:
https://doi.org/10.1016/j.ijcard.2023.03.066

Abstract

Sick sinus syndrome (SSS) and atrial fibrillation (AF) frequently coexist and show a bidirectional relationship. This systematic review and meta-analysis aimed to decipher the precise relationship between SSS and AF, further exploring and comparing different therapy strategies on the occurrence or progression of AF in patients with SSS. A systematic literature search was conducted until November 2022. A total of 35 articles with 37,550 patients were included. Patients with SSS were associated with new-onset AF compared to those without SSS. Catheter ablation was associated with a lower risk of AF recurrence, AF progression, all-cause mortality, stroke and hospitalization of heart failure compared to pacemaker therapy. Regarding the different pacing strategies for SSS, VVI/VVIR has higher risk of new-onset AF than DDD/DDDR. No significant difference was found between AAI/AAIR and DDD/DDDR, as well as between DDD/DDDR and minimal ventricular pacing (MVP) for AF recurrence. AAI/AAIR was associated with higher risk of all-cause mortality when compared to DDD/DDDR, but lower risk of cardiac death when compared to DDD/DDDR. Right atrial septum pacing was associated with a similar risk of new-onset AF or AF recurrence compared to right atrial appendage pacing. SSS is associated with a higher risk of AF. For patients with both SSS and AF, catheter ablation should be considered. This meta-analysis re-emphasizes that high percentage of ventricular pacing should be avoided in patients with SSS in order to decrease AF burden and mortality.

Item Type: Article
DOI/Identification number: 10.1016/j.ijcard.2023.03.066
Uncontrolled keywords: Pacemaker, Sick sinus syndrome, Catheter ablation, Atrial fibrillation
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: National Natural Science Foundation of China (https://ror.org/01h0zpd94)
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 21 Apr 2023 14:36 UTC
Last Modified: 04 Mar 2024 17:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/101004 (The current URI for this page, for reference purposes)

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