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Inhibition of Endotoxin-Induced Uveitis by Methylprednisolone Acetate Nanosuspension in rabbits

Adibkia, Khosro, Omidi, Yadollah, Javadzadeh, Ali R., Barzegar-Jalali, Mohammad, Barar, Jaleh, Maleki, Nasrin, Mohammadi, Ghobad, Nokhodchi, Ali (2007) Inhibition of Endotoxin-Induced Uveitis by Methylprednisolone Acetate Nanosuspension in rabbits. Journal of Ocular Pharmacology and Therapeutics, 23 (5). pp. 421-432. ISSN 1080-7683. (doi:10.1089/jop.2007.0039) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:10060)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1089/jop.2007.0039

Abstract

Purpose: In the current investigation, nanoformulations of methylprednisolone acetate(MPA) were formulated using Eudragit®RS100 to study their impacts on inhibition of

Results: Upon the physicochemical characterizations, no crystal changes or chemical interactions were observed for MPA-Eudragit®RS100 nanoparticles. The 1:2.5 ratio of

RS100 nanosuspension more significantly than the microsuspension of MPA itself in the rabbits with EIU.

Conclusion: Based on our findings, we suggest that the MPA-Eudragit®RS100 nanosuspension may favor the localized controlled ocular delivery of MPA for prevention of inflammatory symptoms in ocular diseases.

Item Type: Article
DOI/Identification number: 10.1089/jop.2007.0039
Subjects: Q Science
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Ali Nokhodchi
Date Deposited: 10 Jul 2008 12:44 UTC
Last Modified: 28 May 2019 13:46 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/10060 (The current URI for this page, for reference purposes)
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