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Recent advances in the discovery, biosynthesis, and therapeutic potential of isocoumarins derived from fungi: a comprehensive update

Tammam, Mohamed A., Gamal El-Din, Mariam I., Abood, Amira, El-Demerdash, Amr (2023) Recent advances in the discovery, biosynthesis, and therapeutic potential of isocoumarins derived from fungi: a comprehensive update. RSC Advances, 13 (12). pp. 8049-8089. ISSN 2046-2069. (doi:10.1039/d2ra08245d) (KAR id:100417)

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Official URL:
https://doi.org/10.1039/d2ra08245d

Abstract

Microorganisms still remain the main hotspots in the global drug discovery avenue. In particular, fungi are highly prolific producers of vast structurally diverse specialized secondary metabolites, which have displayed a myriad of biomedical potentials. Intriguingly, isocoumarins is one distinctive class of fungal natural products polyketides, which demonstrated numerous remarkable biological and pharmacological activities. This review article provides a comprehensive state-of-the-art over the period 2000–2022 about the discovery, isolation, classifications, and therapeutic potentials of isocoumarins exclusively reported from fungi. Indeed, a comprehensive list of 351 structurally diverse isocoumarins were documented and classified according to their fungal sources [16 order/28 family/55 genera] where they have been originally discovered along with their reported pharmacological activities wherever applicable. Also, recent insights around their proposed and experimentally proven biosynthetic pathways are also briefly discussed.

Item Type: Article
DOI/Identification number: 10.1039/d2ra08245d
Uncontrolled keywords: General Chemical Engineering, General Chemistry
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Funders: University of Kent (https://ror.org/00xkeyj56)
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 10 Mar 2023 12:55 UTC
Last Modified: 29 Mar 2023 13:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/100417 (The current URI for this page, for reference purposes)
Tammam, Mohamed A.: https://orcid.org/0000-0001-9314-2697
Gamal El-Din, Mariam I.: https://orcid.org/0000-0001-6377-1775
Abood, Amira: https://orcid.org/0000-0003-0712-9889
El-Demerdash, Amr: https://orcid.org/0000-0001-6459-2955
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