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HPV and Cervical Cancer: A Review of Epidemiology and Screening Uptake in the UK

Choi, Sunyoung, Ismail, Ayden, Pappas-Gogos, George, Boussios, Stergios (2023) HPV and Cervical Cancer: A Review of Epidemiology and Screening Uptake in the UK. Pathogens, 12 (2). Article Number 298. ISSN 2076-0817. (doi:10.3390/pathogens12020298) (KAR id:100170)


Cervical cancer is the fourth most common malignancy in females worldwide, and a leading cause of death in the United Kingdom (UK). The human papillomavirus (HPV) is the strongest risk factor for developing cervical intraepithelial neoplasia and cancer. Across the UK, the national HPV immunisation programme, introduced in 2008, has been successful in protecting against HPV-related infections. Furthermore, the National Health Service (NHS) implemented the cytology-based cervical cancer screening service to all females aged 25 to 64, which has observed a decline in cervical cancer incidence. In the UK, there has been an overall decline in age-appropriate coverage since April 2010. In 2019, the COVID-19 pandemic disrupted NHS cancer screening and immunisation programmes, leading to a 6.8% decreased uptake of cervical cancer screening from the previous year. Engagement with screening has also been associated with social deprivation. In England, incidence rates of cervical cancer were reported to be 65% higher in the most deprived areas compared to the least, with lifestyle factors such as cigarette consumption contributing to 21% of cervical cancer cases. In this article, we provide an update on the epidemiology of cervical cancer, and HPV pathogenesis and transmission, along with the current prevention programmes within the NHS.

Item Type: Article
DOI/Identification number: 10.3390/pathogens12020298
Uncontrolled keywords: Infectious Diseases, Microbiology (medical), General Immunology and Microbiology, Molecular Biology, Immunology and Allergy
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 22 Feb 2023 15:10 UTC
Last Modified: 04 Mar 2024 15:59 UTC
Resource URI: (The current URI for this page, for reference purposes)

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