Chan, Jeffrey Shi Kai, Tang, Pias, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Lee, Yan Hiu Athena, Li, Guoliang, Leung, Fung Ping, Wong, Wing Tak, Liu, Tong, Tse, Gary and others. (2023) Association between immune checkpoint inhibitors and myocardial infarction in Asians: A population‐based self‐controlled case series. Cancer Medicine, 12 (8). pp. 9541-9546. ISSN 2045-7634. (doi:10.1002/cam4.5729) (KAR id:100158)
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Official URL: https://doi.org/10.1002/cam4.5729 |
Abstract
Background: While immune checkpoint inhibitors (ICIs) are associated with elevated cardiovascular risks, evidence of any association between ICIs and myocardial infarction (MI) was scarce, especially in Asians. Methods: Using prospectively collected population‐based data, this self‐controlled case series included patients prescribed an ICI between 1/1/2014 and 31/12/2020 in Hong Kong who had MI within January 1, 2013 to December 31, 2021. Incidence rate ratios (IRRs) for MI during and after ICI exposure were estimated, compared to the year before ICI initiation. Results: Of 3684 identified ICI users, 24 had MI during the study period. MI incidence increased significantly in the first 90 days of exposure (IRR 3.59 [95% confidence interval: 1.31–9.83], p = 0.013), but not days 91–180 (p = 0.148) or ≥181 (p = 0.591) of exposure, nor postexposure (p = 0.923). Sensitivity analyses excluding patients with MI‐related death and incorporating extended exposure periods produced consistent results separately. Conclusions: ICIs were associated with increased MI incidence in Asian Chinese patients during the first 90 days of use, but not later.
Item Type: | Article |
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DOI/Identification number: | 10.1002/cam4.5729 |
Uncontrolled keywords: | cancer management, check point control, clinical cancer research, epidemiology |
Subjects: | R Medicine |
Divisions: | Divisions > Division of Natural Sciences > Kent and Medway Medical School |
SWORD Depositor: | JISC Publications Router |
Depositing User: | JISC Publications Router |
Date Deposited: | 22 Feb 2023 14:31 UTC |
Last Modified: | 18 May 2023 10:34 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/100158 (The current URI for this page, for reference purposes) |
Chan, Jeffrey Shi Kai: | ![]() |
Lee, Yan Hiu Athena: | ![]() |
Liu, Tong: | ![]() |
Tse, Gary: | ![]() |
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