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Association between immune checkpoint inhibitors and myocardial infarction in Asians: A population‐based self‐controlled case series

Chan, Jeffrey Shi Kai, Tang, Pias, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Lee, Yan Hiu Athena, Li, Guoliang, Leung, Fung Ping, Wong, Wing Tak, Liu, Tong, Tse, Gary and others. (2023) Association between immune checkpoint inhibitors and myocardial infarction in Asians: A population‐based self‐controlled case series. Cancer Medicine, 12 (8). pp. 9541-9546. ISSN 2045-7634. (doi:10.1002/cam4.5729) (KAR id:100158)

Abstract

Background: While immune checkpoint inhibitors (ICIs) are associated with elevated cardiovascular risks, evidence of any association between ICIs and myocardial infarction (MI) was scarce, especially in Asians. Methods: Using prospectively collected population‐based data, this self‐controlled case series included patients prescribed an ICI between 1/1/2014 and 31/12/2020 in Hong Kong who had MI within January 1, 2013 to December 31, 2021. Incidence rate ratios (IRRs) for MI during and after ICI exposure were estimated, compared to the year before ICI initiation. Results: Of 3684 identified ICI users, 24 had MI during the study period. MI incidence increased significantly in the first 90 days of exposure (IRR 3.59 [95% confidence interval: 1.31–9.83], p = 0.013), but not days 91–180 (p = 0.148) or ≥181 (p = 0.591) of exposure, nor postexposure (p = 0.923). Sensitivity analyses excluding patients with MI‐related death and incorporating extended exposure periods produced consistent results separately. Conclusions: ICIs were associated with increased MI incidence in Asian Chinese patients during the first 90 days of use, but not later.

Item Type: Article
DOI/Identification number: 10.1002/cam4.5729
Uncontrolled keywords: cancer management, check point control, clinical cancer research, epidemiology
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 22 Feb 2023 14:31 UTC
Last Modified: 18 May 2023 10:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/100158 (The current URI for this page, for reference purposes)

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