Gibbs, A A, Naudts, K H, Azevedo, Ruben T., David, A S (2010) Deletion variant of α2b-adrenergic receptor gene moderates the effect of COMT val158met polymorphism on episodic memory performance. European Neuropsychopharmacology, 20 (4). pp. 272-275. ISSN 0924-977X. (doi:10.1016/j.euroneuro.2009.12.007) (KAR id:99101)
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| Official URL: https://doi.org/10.1016/j.euroneuro.2009.12.007 |
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Abstract
The COMT val158 variant has been associated with impaired cognitive function compared to the met158 variant yet gene–gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the α2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val158 carriers compared to met158 carriers.
| Item Type: | Article |
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| DOI/Identification number: | 10.1016/j.euroneuro.2009.12.007 |
| Subjects: | R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Divisions > Division of Human and Social Sciences > School of Psychology |
| Depositing User: | Ruben Andre Teixeira Azevedo |
| Date Deposited: | 14 Dec 2022 14:41 UTC |
| Last Modified: | 15 Dec 2022 15:20 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/99101 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Azevedo, Ruben T..
| Creator's ORCID: |
 https://orcid.org/0000-0002-6054-7775
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