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Article
| Osborne, James D. and Matthews, Thomas P. and McHardy, Tatiana and Proisy, Nicolas and Cheung, Kwai-Ming J. and Lainchbury, Michael and Brown, Nathan and Walton, Michael I. and Eve, Paul D. and Boxall, Katherine J. and Hayes, Angela and Henley, Alan T. and Valenti, Melanie R. and De Haven Brandon, Alexis K. and Box, Gary and Jamin, Yann and Robinson, Simon P. and Westwood, Isaac M. and van Montfort, Rob L. M. and Leonard, Philip M. and Lamers, Marieke B. A. C. and Reader, John C. and Aherne, G. Wynne and Raynaud, Florence I. and Eccles, Suzanne A. and Garrett, Michelle D. and Collins, Ian (2016) Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). Journal of Medicinal Chemistry, 59 (11). pp. 5221-5237. ISSN 0022-2623. (doi:https://doi.org/10.1021/acs.jmedchem.5b01938) (Full text available) |
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| Wang, Qiming Jane and Silva-Santisteban, M. Cris and Westwood, Isaac M. and Boxall, Kathy and Brown, Nathan and Peacock, Sam and McAndrew, Craig and Barrie, Elaine and Richards, Meirion and Mirza, Amin and Oliver, Antony W. and Burke, Rosemary and Hoelder, Swen and Jones, Keith and Aherne, G. Wynne and Blagg, Julian and Collins, Ian and Garrett, Michelle D. and van Montfort, Rob L. M. (2013) Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. PLoS ONE, 8 (6). e65689. ISSN 1932-6203. (doi:https://doi.org/10.1371/journal.pone.0065689) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Reader, John C. and Matthews, Thomas P. and Klair, Suki and Cheung, Kwai-Ming J. and Scanlon, Jane and Proisy, Nicolas and Addison, Glynn and Ellard, John and Piton, Nelly and Taylor, Suzanne and Cherry, Michael and Fisher, Martin and Boxall, Kathy and Burns, Samantha and Walton, Michael I. and Westwood, Isaac M. and Hayes, Angela and Eve, Paul and Valenti, Melanie and de Haven Brandon, Alexis and Box, Gary and van Montfort, Rob L. M. and Williams, David H. and Aherne, G. Wynne and Raynaud, Florence I. and Eccles, Suzanne A. and Garrett, Michelle D. and Collins, Ian (2011) Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing. Journal of Medicinal Chemistry, 54 (24). pp. 8328-8342. ISSN 0022-2623. (doi:https://doi.org/10.1021/jm2007326) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
