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Article
| Whittaker, Steven R. and Barlow, Clare and Martin, Mathew P. and Mancusi, Caterina and Wagner, Steve and Self, Annette and Barrie, Elaine and te Poele, Robert and Sharp, Swee and Brown, Nathan and Wilson, Stuart and Jackson, Wayne and Fischer, Peter M. and Clarke, Paul A. and Walton, Michael I. and McDonald, Edward and Blagg, Julian and Noble, Martin and Garrett, Michelle D. and Workman, Paul (2018) Molecular profiling and combinatorial activity of CCT068127: A potent CDK2 and CDK9 inhibitor. Molecular Oncology, 12 . pp. 287-304. ISSN 1574-7891. E-ISSN 1878-0261. (doi:https://doi.org/10.1002/1878-0261.12148) (Full text available) |
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| Osborne, James D. and Matthews, Thomas P. and McHardy, Tatiana and Proisy, Nicolas and Cheung, Kwai-Ming J. and Lainchbury, Michael and Brown, Nathan and Walton, Michael I. and Eve, Paul D. and Boxall, Katherine J. and Hayes, Angela and Henley, Alan T. and Valenti, Melanie R. and De Haven Brandon, Alexis K. and Box, Gary and Jamin, Yann and Robinson, Simon P. and Westwood, Isaac M. and van Montfort, Rob L. M. and Leonard, Philip M. and Lamers, Marieke B. A. C. and Reader, John C. and Aherne, G. Wynne and Raynaud, Florence I. and Eccles, Suzanne A. and Garrett, Michelle D. and Collins, Ian (2016) Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). Journal of Medicinal Chemistry, 59 (11). pp. 5221-5237. ISSN 0022-2623. (doi:https://doi.org/10.1021/acs.jmedchem.5b01938) (Full text available) |
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| Lainchbury, Michael and Matthews, Thomas P. and McHardy, Tatiana and Boxall, Kathy J. and Walton, Michael I. and Eve, Paul D. and Hayes, Angela and Valenti, Melanie R. and de Haven Brandon, Alexis K. and Box, Gary and Aherne, G. Wynne and Reader, John C. and Raynaud, Florence I. and Eccles, Suzanne A. and Garrett, Michelle D. and Collins, Ian (2012) Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors. Journal of Medicinal Chemistry, 55 (22). pp. 10229-10240. ISSN 0022-2623. (doi:https://doi.org/10.1021/jm3012933) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Reader, John C. and Matthews, Thomas P. and Klair, Suki and Cheung, Kwai-Ming J. and Scanlon, Jane and Proisy, Nicolas and Addison, Glynn and Ellard, John and Piton, Nelly and Taylor, Suzanne and Cherry, Michael and Fisher, Martin and Boxall, Kathy and Burns, Samantha and Walton, Michael I. and Westwood, Isaac M. and Hayes, Angela and Eve, Paul and Valenti, Melanie and de Haven Brandon, Alexis and Box, Gary and van Montfort, Rob L. M. and Williams, David H. and Aherne, G. Wynne and Raynaud, Florence I. and Eccles, Suzanne A. and Garrett, Michelle D. and Collins, Ian (2011) Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing. Journal of Medicinal Chemistry, 54 (24). pp. 8328-8342. ISSN 0022-2623. (doi:https://doi.org/10.1021/jm2007326) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
