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Number of items: 36.
Article
| Alanen, Heli I. and Walker, Kelly L. and Lourdes Velez Suberbie, M. and Matos, Cristina F.R.O. and Bönisch, Sarah and Freedman, Robert B. and Keshavarz-Moore, Eli and Ruddock, Lloyd W. and Robinson, Colin (2015) Efficient export of human growth hormone, interferon alpha2b and antibody fragments to the periplasm by the Escherichia coli Tat pathway in the absence of prior disulfide bond formation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853 (3). pp. 756-763. ISSN 0167-4889. (doi:https://doi.org/10.1016/j.bbamcr.2014.12.027) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Matos, Cristina F. R. O. and Robinson, Colin and Alanen, Heli I. and Prus, Piotr and Uchida, Yuko and Ruddock, Lloyd W. and Freedman, Robert B. and Keshavarz-Moore, Eli (2014) Efficient export of prefolded, disulfide-bonded recombinant proteins to the periplasm by the Tat pathway in Escherichia coli CyDisCo strains. Biotechnology Progress, 30 (2). pp. 281-290. ISSN 8756-7938. (doi:https://doi.org/10.1002/btpr.1858) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Matos, Cristina F.R.O. and Alanen, Heli I. and Prus, Piotr and Uchida, Yuko and Freedman, Robert B. and Keshavarz-Moore, Eli and Robinson, Colin and Ruddock, Lloyd W. (2013) Efficient export of prefolded, disulfide-bonded recombinant proteins to the periplasm by the Tat pathway inEscherichia coliCyDisCo strains. Biotechnology Progress, 30 (2). pp. 281-290. ISSN 8756-7938. (doi:https://doi.org/10.1002/btpr.1858) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Wallis, Anne Katrine and Sidhu, Ateesh and Byrne, Lee J. and Howard, Mark J. and Ruddock, Lloyd W. and Williamson, Richard A. and Freedman, Robert B. (2009) The ligand-binding b' domain of human protein disulphide-isomerase mediates homodimerization. Protein Science, 18 (12). pp. 2569-2577. ISSN 0961-8368. (doi:https://doi.org/10.1002/pro.270) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Byrne, Lee J. and Sidhu, Ateesh and Wallis, Anne Katrine and Ruddock, Lloyd W. and Freedman, Robert B. and Howard, Mark J. and Williamson, Richard A. (2009) Mapping of the ligand-binding site on the b' domain of human PDI: interaction with peptide ligands and the x-linker region. Biochemical Journal, 423 (2). pp. 209-217. ISSN 0264-6021. (doi:https://doi.org/10.1042/BJ20090565) (Full text available) |
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| Rowe, Michelle L. and Ruddock, Lloyd W. and Kelly, Geoff and Schmidt, Jürgen M. and Williamson, Richard A. and Howard, Mark J. (2009) Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase. Biochemistry, 48 (21). pp. 4596-4606. ISSN 0006-2960. (doi:https://doi.org/10.1021/bi9003342) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Nguyen, Van Dat and Wallis, Katrine and Howard, Mark J. and Haapalainen, Antti E. and Salo, Kirsi E. H. and Saaranen, Mirva J. and Sidhu, Ateesh and Wierenga, Rik K. and Freedman, Robert B. and Ruddock, Lloyd W. and Williamson, Richard A. (2008) Alternative conformations of the x region of human protein disulphide-isomerase modulate exposure of the substrate binding b' domain. Journal of Molecular Biology, 383 (5). pp. 1144-1155. ISSN 0022-2836. (doi:https://doi.org/10.1016/j.jmb.2008.08.085) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Karala, Anna-Riikka and Psarrakos, Panagiotis and Ruddock, Lloyd W. and Klappa, Peter (2007) Protein disulfide isomerases from C-elegans are equally efficient at thiol-disulfide exchange in simple peptide-based systems but show differences in reactivity towards protein substrates. Antioxidants and Redox Signaling, 9 (11). pp. 1815-1823. ISSN 1557-7716. (doi:https://doi.org/10.1089/ars.2007.1624) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Alanen, Heli I. and Williamson, Richard A. and Howard, Mark J. and Hatahet, Feras S. and Salo, Kirsi E. H. and Kauppila, Annika and Kellokumpu, Sakari and Ruddock, Lloyd W. (2006) ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57. Journal of Biological Chemistry, 281 (44). pp. 33727-33738. ISSN 0021-9258. (doi:https://doi.org/10.1074/jbc.M604314200) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Pirneskoski, Annamari and Klappa, Peter and Lobell, Mario and Williamson, Richard A. and Byrne, Lee J. and Alanen, Heli I. and Salo, Kirsi E. H. and Kivirikkos, Kari I. and Freedman, Robert B. and Ruddock, Lloyd W. (2004) Molecular characterization of the principal substrate binding site of the ubiquitous folding catalyst protein disulfide isomerase. Journal of Biological Chemistry, 279 (11). pp. 10374-10381. ISSN 0021-9258. (doi:https://doi.org/10.1074/jbc.M312193200) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) |
![[img]](https://kar.kent.ac.uk/style/images/fileicons/application_pdf.png)
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| Cheesman, Caroline and Freedman, Robert B. and Ruddock, Lloyd W. (2004) The disassembly and reassembly of mutants of Escherichia coli heat-labile enterotoxin: Replacement of proline 93 does not abolish the reassembly-competent and reassembly-incompetent states. Biochemistry, 43 (6). pp. 1618-1625. ISSN 0006-2960. (doi:https://doi.org/10.1021/bi035499z) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Klappa, Peter and Bass, Rosemary and Ruddock, Lloyd W. and Freedman, Robert B. (2004) A major fraction of endoplasmic reticulum-located glutathione is present as mixed disulfides with protein. Journal of Biological Chemistry, 279 (7). pp. 5257-5262. ISSN 0021-9258. (doi:https://doi.org/10.1074/jbc.M304951200) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Cheesman, Caroline and Ruddock, Lloyd W. and Freedman, Robert B. (2004) The refolding and reassembly of Escherichia coli heat-labile enterotoxin B-subunit: Analysis of reassembly-competent and reassembly-incompetent unfolded states. Biochemistry, 43 (6). pp. 1609-1617. ISSN 0006-2960. (doi:https://doi.org/10.1021/bi0354987) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Morgan, Byron J. T. and Ridout, Martin S. and Ruddock, Lloyd W. (2003) Models for yeast prions. Biometrics, 59 (3). pp. 562-569. ISSN 0006-341X. (doi:https://doi.org/10.1111/1541-0420.00066) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Alanen, Heli I. and Williamson, Richard A. and Howard, Mark J. and Lappi, Anna-Kaisa and Jantti, Heli P. and Rautio, Sini M. and Kellokumpu, Sakari and Ruddock, Lloyd W. (2003) Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member. Journal of Biological Chemistry, 278 (31). pp. 28912-28920. ISSN 0021-9258. (doi:https://doi.org/10.1074/jbc.M304598200) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Grantham, J. and Ruddock, Lloyd W. and Roobol, Anne and Carden, Martin J. (2002) Eukaryotic chaperonin containing T-complex polypeptide 1 interacts with filamentous actin and reduces the initial rate of actin polymerization in vitro. Cell Stress and Chaperones, 7 (3). pp. 235-242. ISSN 1355-8145. (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) |
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| Pirneskoski, Annamari and Ruddock, Lloyd W. and Klappa, Peter and Freedman, Robert B. and Kivirikkos, Kari I. and Koivunen, Peppi (2001) Domains b' and a' of protein disulfide isomerase fulfill the minimum requirement for function as a subunit of prolyl 4-hydroxylase. The N-terminal domains a and b enhances this function and can be substituted in part by those of ERp57. Journal of Biological Chemistry, 276 (14). pp. 11287-11293. ISSN 0021-9258. (doi:https://doi.org/10.1074/jbc.M010656200) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Webb, Helen M. and Ruddock, Lloyd W. and Marchant, Rosalyn J. and Jonas, Kim and Klappa, Peter (2001) Interaction of the periplasmic peptidylprolyl cis-trans isomerase SurA with model peptides. The N-terminal region of SurA id essential and sufficient for peptide binding. Journal of Biological Chemistry, 276 (49). pp. 45622-45627. ISSN 0021-9258. E-ISSN 1083-351X. (doi:https://doi.org/10.1074/jbc.M107508200) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) |
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| Klappa, Peter and Freedman, Robert B. and Langenbuch, Martina and Lan, Michael S. and Robinson, Gary K. and Ruddock, Lloyd W. (2001) The pancreas-specific protein disulphide-isomerase PDIp interacts with a hydroxyaryl group in ligands. Biochemical Journal, 354 . pp. 553-559. ISSN 0264-6021. (doi:https://doi.org/10.1042/0264-6021:3540553) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) |
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| Klappa, Peter and Koivunen, Peppi and Pirneskoski, Annamari and Karvonen, P. and Ruddock, Lloyd W. and Kivirikkos, Kari I. and Freedman, Robert B. (2000) Mutations that destabilize the a ' domain of human protein-disulfide isomerase indirectly affect peptide binding. Journal of Biological Chemistry, 275 (18). pp. 13213-13218. ISSN 0021-9258. (doi:https://doi.org/10.1074/jbc.275.18.13213) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Freedman, Robert B. and Klappa, Peter (2000) Specificity in substrate binding by protein folding catalysts: Tyrosine and tryptophan residues are the recognition motifs for the binding of peptides to the pancreas-specific protein disulfide isomerase PDIp. Protein Science, 9 (4). pp. 758-764. ISSN 0961-8368. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Eaglestone, Simon S. and Ruddock, Lloyd W. and Cox, Brian S. and Tuite, Mick F. (2000) Guanidine hydrochloride blocks a critical step in the propagation of the prion-like determinant [PSI+] of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America, 97 (1). pp. 240-244. ISSN 0027-8424. (doi:https://doi.org/10.1073/pnas.97.1.240) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Klappa, Peter (1999) Oxidative stress: Protein folding with a novel redox switch. Current Biology, 9 (11). R400-R402. ISSN 0960-9822. (doi:https://doi.org/10.1016/S0960-9822(99)80253-X) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Freedman, Robert B. and Dunn, Angela D. and Ruddock, Lloyd W. (1998) Protein folding: A missing redox link in the endoplasmic reticulum. Current Biology, 8 (13). R468-R470. ISSN 0960-9822. (doi:https://doi.org/10.1016/S0960-9822(98)70295-7) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Klappa, Peter and Stromer, Thusnelda and Zimmermann, Richard and Ruddock, Lloyd W. and Freedman, Robert B. (1998) A pancreas-specific glycosylated protein disulphide-isomerase binds to misfolded proteins and peptides with an interaction inhibited by oestrogens. European Journal of Biochemistry, 254 (1). pp. 63-69. ISSN 0014-2956. (doi:https://doi.org/10.1046/j.1432-1327.1998.2540063.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Klappa, Peter and Ruddock, Lloyd W. and Darby, Nigel J. and Freedman, Robert B. (1998) The b ' domain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins. Embo Journal, 17 (4). pp. 927-935. ISSN 0261-4189. (doi:https://doi.org/10.1093/emboj/17.4.927) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Webb, Helen M. and Ruston, Stephen P. and Cheesman, Caroline and Freedman, Robert B. and Hirst, Timothy R. (1996) A pH-dependent conformational change in the B-subunit pentamer of Escherichia coli heat-labile enterotoxin: Structural basis and possible functional role for a conserved feature of the AB(5) toxin family. Biochemistry, 35 (50). pp. 16069-16076. ISSN 0006-2960. (doi:https://doi.org/10.1021/bi961865l) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Coen, Jeremy J. F. and Cheesman, Caroline and Freedman, Robert B. and Hirst, Timothy R. (1996) Assembly of the B subunit pentamer of Escherichia coli heat-labile enterotoxin - Kinetics and molecular basis of rate-limiting steps in vitro. Journal of Biological Chemistry, 271 (32). pp. 19118-19123. ISSN 0021-9258. (doi:https://doi.org/10.1074/jbc.271.32.19118) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Hirst, Timothy R. and Freedman, Robert B. (1996) pH-dependence of the dithiol-oxidizing activity of DsbA (a periplasmic protein thiol:disulphide oxidoreductase) and protein disulphide-isomerase: Studies with a novel simple peptide substrate. Biochemical Journal, 315 . pp. 1001-1005. ISSN 0264-6021. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Ruston, Stephen P. and Kelly, Sharon M. and Price, Nicholas C. and Freedman, Robert B. and Hirst, Timothy R. (1995) Kinetics of acid-mediated disassembly of the b-subunit pentamer of escherichia-coli heat-labile enterotoxin - molecular-basis of ph stability. Journal of Biological Chemistry, 270 (50). pp. 29953-29958. ISSN 0021-9258. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
Conference or workshop item
| Hirst, Timothy R. and Hilary, J.B. and Ruddock, Lloyd W. and Yu, J. (1995) Translocation of folded proteins across bacterial outer membranes: A novel secretory phenomenon. In: Biochemical Society Transactions. Portland Press pp. 985-991. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
Datasets / databases
| Rowe, Michelle L. and Ruddock, Lloyd W. and Kelly, Geoff and Schmidt, Jürgen M. and Williamson, Richard A. and Howard, Mark J. (2009) Solution structure of Oxidised ERp18. RSCB/PDB Protein Data Bank PDB formatted text file. 8.1MB. Located at: http://www.rcsb.org/pdb/explore/explore.do?pdbId=2K8V. https://doi.org/10.2210/pdb2k8v/pdb. (doi:https://doi.org/10.2210/pdb2k8v/pdb) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Rowe, Michelle L. and Alanen, Heli I. and Ruddock, Lloyd W. and Kelly, Geoff and Schmidt, Jürgen M. and Williamson, Richard A. and Howard, Mark J. (2009) 1H, 13C, 15N chemical shift assignments for oxidised ERp18. Biological Magnetic Resonance Data Bank (BMRB), Madison, Wisconsin, USA NMR-STAR formatted text file. 102kB. Located at: http://www.bmrb.wisc.edu/data_library/generate_summary.php?bmrbId=15964. BMRB entry 15964. (doi:BMRB entry 15964) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Rowe, Michelle L. and Alanen, Heli I. and Ruddock, Lloyd W. and Kelly, Geoff and Schmidt, Jürgen M. and Williamson, Richard A. and Howard, Mark J. (2009) 1H, 13C, 15N chemical shift assignments for reduced ERp18. Biological Magnetic Resonance Data Bank (BMRB), Madison, Wisconsin, USA NMR-STAR formatted text file. 53kB. Located at: http://www.bmrb.wisc.edu/data_library/generate_summary.php?bmrbId=7430. BMRB entry 7430. (doi:BMRB entry 7430) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
Review
| Freedman, Robert B. and Klappa, Peter and Ruddock, Lloyd W. (2002) Protein disulfide isomerases exploit synergy between catalytic and specific binding domains. EMBO Reports, 3 (2). pp. 136-140. ISSN 1469-221X. (doi:https://doi.org/10.1093/embo-reports/kvf035) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Freedman, Robert B. and Klappa, Peter and Ruddock, Lloyd W. (2002) Model peptide substrates and ligands in analysis of action of mammalian protein disulfide-isomerase. Methods in Enzymology, 348 . pp. 342-354. ISSN 0076-6879. (doi:https://doi.org/10.1016/S0076-6879(02)48653-3) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
