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Number of items: 3.

Article

Whittaker, Steven R. and Barlow, Clare and Martin, Mathew P. and Mancusi, Caterina and Wagner, Steve and Self, Annette and Barrie, Elaine and te Poele, Robert and Sharp, Swee and Brown, Nathan and Wilson, Stuart and Jackson, Wayne and Fischer, Peter M. and Clarke, Paul A. and Walton, Michael I. and McDonald, Edward and Blagg, Julian and Noble, Martin and Garrett, Michelle D. and Workman, Paul (2018) Molecular profiling and combinatorial activity of CCT068127: A potent CDK2 and CDK9 inhibitor. Molecular Oncology, 12 . pp. 287-304. ISSN 1574-7891. E-ISSN 1878-0261. (doi:https://doi.org/10.1002/1878-0261.12148) (Full text available)
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Osborne, James D. and Matthews, Thomas P. and McHardy, Tatiana and Proisy, Nicolas and Cheung, Kwai-Ming J. and Lainchbury, Michael and Brown, Nathan and Walton, Michael I. and Eve, Paul D. and Boxall, Katherine J. and Hayes, Angela and Henley, Alan T. and Valenti, Melanie R. and De Haven Brandon, Alexis K. and Box, Gary and Jamin, Yann and Robinson, Simon P. and Westwood, Isaac M. and van Montfort, Rob L. M. and Leonard, Philip M. and Lamers, Marieke B. A. C. and Reader, John C. and Aherne, G. Wynne and Raynaud, Florence I. and Eccles, Suzanne A. and Garrett, Michelle D. and Collins, Ian (2016) Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). Journal of Medicinal Chemistry, 59 (11). pp. 5221-5237. ISSN 0022-2623. (doi:https://doi.org/10.1021/acs.jmedchem.5b01938) (Full text available)
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Wang, Qiming Jane and Silva-Santisteban, M. Cris and Westwood, Isaac M. and Boxall, Kathy and Brown, Nathan and Peacock, Sam and McAndrew, Craig and Barrie, Elaine and Richards, Meirion and Mirza, Amin and Oliver, Antony W. and Burke, Rosemary and Hoelder, Swen and Jones, Keith and Aherne, G. Wynne and Blagg, Julian and Collins, Ian and Garrett, Michelle D. and van Montfort, Rob L. M. (2013) Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. PLoS ONE, 8 (6). e65689. ISSN 1932-6203. (doi:https://doi.org/10.1371/journal.pone.0065689) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

This list was generated on Tue May 21 11:58:12 2019 BST.