Skip to main content

Deletion of the 5-HT3A-receptor subunit blunts the induction of cocaine sensitization

Hodge, C. W., Bratt, Alison M., Kelley, S. P. (2007) Deletion of the 5-HT3A-receptor subunit blunts the induction of cocaine sensitization. Genes, Brain and Behavior, 7 (1). pp. 96-102. ISSN 1601-1848. (doi:10.1111/j.1601-183X.2007.00332.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1111/j.1601-183X.2007.00332.x

Abstract

Serotonin (5-HT) receptors are classified into seven groups (5-HT1–7), comprising at least 14 structurally and pharmacologically distinct receptor subtypes. Pharmacological antagonism of ionotropic 5-HT3 receptors has been shown to modulate both behavioral and neurochemical aspects of the induction of sensitization to cocaine. It is not known, however, if specific molecular subunits of the 5-HT3 receptor influence the development of cocaine sensitization. To address this question, we studied the effects of acute and chronic intermittent cocaine administration in mice with a targeted deletion of the gene for the 5-HT3A-receptor subunit (5-HT3A?/?). 5-HT3A (?/?) mice showed blunted induction of cocaine-induced locomotor sensitization as compared with wild-type littermate controls. 5-HT3A (?/?) mice did not differ from wild-type littermate controls on measures of basal motor activity or response to acute cocaine treatment. Enhanced locomotor response to saline injection following cocaine sensitization was observed equally in 5-HT3A (?/?) and wild-type mice suggesting similar conditioned effects associated with chronic cocaine treatment. These data show a role for the 5-HT3A-receptor subunit in the induction of behavioral sensitization to cocaine and suggest that the 5-HT3A molecular subunit modulates neurobehavioral adaptations to cocaine, which may underlie aspects of addiction.

Item Type: Article
DOI/Identification number: 10.1111/j.1601-183X.2007.00332.x
Subjects: Q Science
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Alison Bratt
Date Deposited: 06 Dec 2017 12:35 UTC
Last Modified: 29 May 2019 19:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/65030 (The current URI for this page, for reference purposes)
  • Depositors only (login required):