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Inhibition of Neuroblastoma Tumor Growth by Targeted Delivery of MicroRNA-34a Using Anti-Disialoganglioside GD2 Coated Nanoparticles

Tivnan, Amanda, Orr, Wayne Shannon, Gubala, Vladimir, Nooney, Robert, Williams, David E., McDonagh, Colette, Prenter, Suzanne, Harvey, Harry, Domingo-Fernandez, Raquel, Bray, Isabella M, and others. (2012) Inhibition of Neuroblastoma Tumor Growth by Targeted Delivery of MicroRNA-34a Using Anti-Disialoganglioside GD2 Coated Nanoparticles. PLoS ONE, 7 (5). e38129. ISSN 1932-6203. (doi:10.1371/journal.pone.0038129) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1371/journal.pone.0038129

Abstract

Neuroblastoma is one of the most challenging malignancies of childhood, being associated with the highest death rate in paediatric oncology, underlining the need for novel therapeutic approaches. Typically, patients with high risk disease undergo an initial remission in response to treatment, followed by disease recurrence that has become refractory to further treatment. Here, we demonstrate the first silica nanoparticle-based targeted delivery of a tumor suppressive, pro-apoptotic microRNA, miR-34a, to neuroblastoma tumors in a murine orthotopic xenograft model. These tumors express high levels of the cell surface antigen disialoganglioside GD2 (GD2), providing a target for tumor-specific delivery.

Item Type: Article
DOI/Identification number: 10.1371/journal.pone.0038129
Additional information: a) The author made a substantial contribution either to the conception and design of the study; or to the organisation of the conduct of the study or to carrying out the study (including acquisition of study data); or to analysis and interpretation of the study data. b) The author helped draft the output; or critique the output for important intellectual content.; number of additional authors: 9;
Subjects: Q Science
R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Stewart Brownrigg
Date Deposited: 07 Mar 2014 00:05 UTC
Last Modified: 23 Jan 2020 04:08 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/40397 (The current URI for this page, for reference purposes)
Gubala, Vladimir: https://orcid.org/0000-0001-6301-3632
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