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Trifluoroacetyl HYNIC derivatives: An efficient strategy in TC-99m peptide radiolabelling

Surfraz, M. Bashir-Uddin, King, Robert C., Mather, Stephen J., Biagini, Stefano C. G., Blower, Philip J. (2007) Trifluoroacetyl HYNIC derivatives: An efficient strategy in TC-99m peptide radiolabelling. Journal of Medical Chemistry, 50 (6). pp. 1418-1422. ISSN 0340-6997. (doi:10.1021/jm061274l) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:13261)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1021/jm061274l

Abstract

Fmoc-lys(HYNIC-Boc)-OH, a precursor for solid-phase synthesis of 99mTc-labeled peptides, was synthesized efficiently without HPLC purification. HPLC-ESMS showed that deprotection and decoupling of peptide from the resin with trifluoroacetic acid gave initially HYNIC-peptide, which was trifluoroacetylated upon prolonged incubation. The trifluoroacetyl-HYNIC group was hydrolyzed during 99mTc labeling, rendering deprotection unnecessary. Trifluoroacetyl-HYNIC peptide was 99mTc-labeled as efficiently, producing the same product, as HYNIC-peptide. These modifications enhance the versatility of HYNIC for 99mTc peptide labeling.

Item Type: Article
DOI/Identification number: 10.1021/jm061274l
Additional information: Meeting abstract.
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Sciences > School of Biosciences
Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Faculties > Sciences > School of Physical Sciences
Depositing User: Stefano Biagini
Date Deposited: 05 Oct 2009 18:04 UTC
Last Modified: 15 Jan 2020 04:01 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/13261 (The current URI for this page, for reference purposes)
Biagini, Stefano C. G.: https://orcid.org/0000-0002-4713-5127
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