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Number of items: 38.
Article
| Lloyd, J.R. and Hirst, Timothy R. and Bunch, Alan William (1997) Hollow-fibre bioreactors compared to batch and chemostat culture for the production of a recombinant toxoid by a marine Vibrio. Applied Microbiology and Biotechnology, 48 (2). pp. 155-161. ISSN 0175-7598. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Webb, Helen M. and Ruston, Stephen P. and Cheesman, Caroline and Freedman, Robert B. and Hirst, Timothy R. (1996) A pH-dependent conformational change in the B-subunit pentamer of Escherichia coli heat-labile enterotoxin: Structural basis and possible functional role for a conserved feature of the AB(5) toxin family. Biochemistry, 35 (50). pp. 16069-16076. ISSN 0006-2960. (doi:https://doi.org/10.1021/bi961865l) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Coen, Jeremy J. F. and Cheesman, Caroline and Freedman, Robert B. and Hirst, Timothy R. (1996) Assembly of the B subunit pentamer of Escherichia coli heat-labile enterotoxin - Kinetics and molecular basis of rate-limiting steps in vitro. Journal of Biological Chemistry, 271 (32). pp. 19118-19123. ISSN 0021-9258. (doi:https://doi.org/10.1074/jbc.271.32.19118) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Hirst, Timothy R. and Freedman, Robert B. (1996) pH-dependence of the dithiol-oxidizing activity of DsbA (a periplasmic protein thiol:disulphide oxidoreductase) and protein disulphide-isomerase: Studies with a novel simple peptide substrate. Biochemical Journal, 315 . pp. 1001-1005. ISSN 0264-6021. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Nashar, Toufic O. and Williams, Neil A. and Hirst, Timothy R. (1996) Cross-linking of cell surface ganglioside GM1 induces the selective apoptosis of mature CD8(+) T lymphocytes. International Immunology, 8 (5). pp. 731-736. ISSN 0953-8178. (doi:https://doi.org/10.1093/intimm/8.5.731) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Lencer, W.I. and Madara, J.L. and Jobling, M.G. and Holmes, R.K. and Hirst, Timothy R. (1996) Proteolytic activation of cholera toxin (CT) and E-coli labile toxin (LT) by intestinal epithelia. Gastroenterology, 110 (4). A342-A342. ISSN 0016-5085. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Nashar, Toufic O. and Webb, Helen M. and Eaglestone, Simon S. and Williams, Neil A. and Hirst, Timothy R. (1996) Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: Receptor binding is essential and induces differential modulation of lymphocyte subsets. Proceedings of the National Academy of Sciences of the United States of America, 93 (1). pp. 226-230. ISSN 0027-8424. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Green, E.A. and Botting, Catherine and Webb, Helen M. and Hirst, Timothy R. and Randall, Richard Edward (1996) Construction, purification and immunogenicity of antigen-antibody-LTB complexes. Vaccine, 14 (10). pp. 949-958. ISSN 0264-410X. (doi:https://doi.org/10.1016/0264-410X(96)00039-4) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Karlsson, Karl-Anders and Teneberg, Susann and Angstrom, Jonas and Kjellberg, Anders and Hirst, Timothy R. and Bergstrom, Jorgen and Miller-Podraza, Halina (1996) Unexpected carbohydrate cross-binding by Escherichia coli heat-labile enterotoxin. Recognition of human and rabbit target cell glycoconjugates in comparison with cholera toxin. Bioorganic & Medicinal Chemistry, 4 (11). pp. 1919-1928. ISSN 0968-0896. (doi:https://doi.org/10.1016/S0968-0896(96)00174-5) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruddock, Lloyd W. and Ruston, Stephen P. and Kelly, Sharon M. and Price, Nicholas C. and Freedman, Robert B. and Hirst, Timothy R. (1995) Kinetics of acid-mediated disassembly of the b-subunit pentamer of escherichia-coli heat-labile enterotoxin - molecular-basis of ph stability. Journal of Biological Chemistry, 270 (50). pp. 29953-29958. ISSN 0021-9258. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Lencer, W.I. and Constable, C. and Moe, S. and Jobling, M.G. and Webb, Helen M. and Ruston, Stephen P. and Madara, J.L. and Hirst, Timothy R. and Holmes, R.K. (1995) Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL. Journal of Cell Biology, 131 (4). pp. 951-962. ISSN 0021-9525. (doi:https://doi.org/10.1083/jcb.131.4.951) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Amin, Tehmina and Larkins, Audrey and James, Roger F. L. and Hirst, Timothy R. (1995) Generation of a Monocloal-Antibody that Recognizes the Amino-Terminal Decapeptide of the B-Subunit of Rscheichia-Coli Heat-Labile Enterotoxin - a New Probe for Studying Toxn Assemy Intermediates. Journal of Biological Chemistry, 270 (34). pp. 20143-20150. ISSN 0021-9258. (doi:https://doi.org/10.1074/jbc.270.34.20143) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Nashar, Toufic O. and Hirst, Timothy R. (1995) Immunoregulatory role of H-2 and intra-H-2 alleles on antibody responses to recombinant preparations of B-subunits of Escherichia coli heat-labile enterotoxin (rEtxB) and cholera toxin (rCtxB). Vaccine, 13 (9). pp. 803-810. ISSN 0264-410X. (doi:https://doi.org/10.1016/0264-410X(94)00077-Z) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Lencer, W.I. and Hirst, Timothy R. and Jobling, M.G. and Madara, J.L. and Holmes, R.K. (1995) Targeting of cholera-toxin and escherichia-coli labile toxin in polarized epithelia - role of c-terminal k(r)del. Gastroenterology, 108 (4). A300-A300. ISSN 0016-5085. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Lowe, E.D. and Freedman, Robert B. and Hirst, Timothy R. and Barth, P.T. (1995) Cloning and expression of vibrio-cholerae dsba, a gene encoding a periplasmic protein disulfide-isomerase. Biochemical Society Transactions, 23 (1). S64-S64. ISSN 0300-5127. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Loregian, Arianna and Marcello, Alessandro and Hirst, Timothy R. and Marsden, H.S. and Palu, Giorgio (1995) Construction of a fusion protein between b-subunit of escherichia-coli heat-labile enterotoxin and the c-terminus of herpes-simplex-virus dna-polymerase. Biochemical Society Transactions, 23 (1). S61-S61. ISSN 0300-5127. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Teneberg, Susann and Hirst, Timothy R. and Angstrom, Jonas and Karlsson, Karl-Anders (1994) Comparison of the Glycolipid-Binding Specificities of Cholera-Toxin and Porcin Escherichia-Coli Heart-Labile Enterotoxin - Identification of a Receptor-Active Non-Ganglioside Glycolipid for the Heart-Labile toxin in Infant Rabit Small- Intenstin. Glycoconjugate Journal, 11 (6). pp. 533-540. ISSN 0282-0080. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Marcello, Alessandro and Loregian, Arianna and Cross, A. and Marsden, H.S. and Hirst, Timothy R. and Palu, Giorgio (1994) Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit. Proceedings of the National Academy of Sciences of the United States of America, 91 (19). pp. 8994-8998. ISSN 0027-8424. (doi:https://doi.org/10.1073/pnas.91.19.8994) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Freedman, Robert B. and Hirst, Timothy R. and Tuite, Mick F. (1994) Protein Disulfide-Isomerase Build Bridges in Protein-Folding. Trends in Biochemical Sciences, 19 (8). pp. 331-336. ISSN 0968-0004. (doi:https://doi.org/10.1016/0968-0004(94)90072-8) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Amin, Tehmina and Hirst, Timothy R. (1994) Purification of the B-Subunit Oligomer of Escherichia-Coli Heat-Labile Enterotoxin by Heterologous Expression and Secretion in a Marine Virio. Protein Expression and Purification, 5 (2). pp. 198-204. ISSN 1046-5928. (doi:https://doi.org/10.1006/prep.1994.1031) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Marcello, Alessandro and Loregian, Arianna and Palu, Giorgio and Hirst, Timothy R. (1994) Efficient extracellular production of hybrid escherichia-coli heat-labile enterotoxin-b subunits in a marine vibrio. FEMS Microbiology Letters, 117 (1). pp. 47-51. ISSN 0378-1097. (doi:https://doi.org/10.1111/j.1574-6968.1994.tb06741.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Findlay, G. and Hirst, Timothy R. (1994) Escherichia-Coli and Vibrio- Cholerae Strains Deficient in an Enzyme Involved in Disufide Bond Formation(DSBA) Show an Increase in Senitivity to Dithiothreitol. Biochemical Society Transactions, 22 (1). S77-S77. ISSN 0300-5127. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ascencio, Felipe and Hirst, Timothy R. and Wadstrom, Torkel (1994) A Secreted Lectin from Aeromonas-Hydrophila with Affinity for Collagen. Journal of Cellular Biochemistry, . p. 68. ISSN 0730-2312. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Yu, Jun and McLaughlin, Stephen H. and Freedman, Robert B. and Hirst, Timothy R. (1993) Cloning and active site mutagenesis of Vibrio cholerae DsbA, a periplasmic enzyme that catalyzes disulfide bond formation. Journal of Biological Chemistry, 268 (6). pp. 4326-4330. ISSN 0021-9258. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Streatfield, S.J. and Sandkvist, M. and Sixma, T.K. and Bagdasarian, M. and Hol, W.G.J. and Hirst, Timothy R. (1992) Intermolecular interactions between the a-subunit and b-subunit of heat-labile enterotoxin from escherichia-coli promote holotoxin assembly and stability invivo. Proceedings of the National Academy of Sciences of the United States of America, 89 (24). pp. 12140-12144. ISSN 0027-8424. (doi:https://doi.org/10.1073/pnas.89.24.12140) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Yu, J. and Webb, Helen M. and Hirst, Timothy R. (1992) A homologue of the Escherichia coli DsbA protein involved in disulphide bond formation is required for enterotoxin biogenesis in Vibrio cholerae. Molecular Microbiology, 6 (14). pp. 1949-1958. ISSN 0950-382X. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Leece, Robin and Hirst, Timothy R. (1992) Expression of the B-Subunit of Escherichia-Coli Heat-Labile Enterotoxin in a Marine Vibrio and In a Mutant That Is Pleiotropically Defective In the Secretion of Extracellular Proteins. Journal of General Microbiology, 138 . pp. 719-724. ISSN 0022-1287. (doi:https://doi.org/10.1099/00221287-138-4-719) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
Conference or workshop item
| Hirst, Timothy R. and Hilary, J.B. and Ruddock, Lloyd W. and Yu, J. (1995) Translocation of folded proteins across bacterial outer membranes: A novel secretory phenomenon. In: Biochemical Society Transactions. Portland Press pp. 985-991. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Aitken, Robert and Hirst, Timothy R. (1995) Bacterial Toxins as Novel Antigen Delivery Sysems. In: Livestock Production Sience. Elsevier Science Bv pp. 163-172. (doi:https://doi.org/10.1016/0301-6226(95)00017-F) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Ruston, Stephen P. and Eaglestone, Simon S. and Webb, Helen M. and Hirst, Timothy R. (1995) Strategies for the purification of intact and proteolytically-activated native and engineered heat-labile enterotoxins of escherichia-coli. In: Biochemical Society Transactions. Portland Press, London, England S55-S55. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Yu, J. and Hirst, Timothy R. (1995) A pleiotropic secretion mutant of aeromonas-hydrophila is unable to secrete heterologously expressed escherichia-coli enterotoxin - implication for common mechanisms of protein secretion. In: Biochemical Society Transactions. Portland Press, London, England S34-S34. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Eaglestone, Simon S. and Hirst, Timothy R. (1995) Preparation of a Fusion Protein for Vaccintion Against Escherichia-Coli Enterotoxins. In: Biochemical Society Transactions. Portland Press S54-S54. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Webb, Helen M. and Sixma, T.K. and Hol, W.G.J. and Hirst, Timothy R. (1994) Analysis by Site-Directed Mutagenesis of Important Residues Invoved in the Assembly of Escherichia-Coli Heart-Labile NALYSIS BY SITE-DIRECTED MUTAGENESIS OF IMPORTANT RESIDUES Enterotoxin. In: Freer, J. and Aitken, Robert and Alouf, J.E and Boulnois, G. and Falmagne, P. and Fehrenbach, F. and Montecucco, C. and Piemont, Y. and Rappuoli, Rino and Wadstrom, Torkel and Witholt, B., eds. Bacterial Protein Toxins -Sixth European Workshop. Gustav Fischer Verlag pp. 204-205. ISBN 3-437-11535-9. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Armin, Tehmina and James, Roger F. L. and Hirst, Timothy R. (1994) The B-subunit of Escherichia-Coli Heat-Labile Enterotoxin - its Purificaltion and Potential Applications. In: Freer, J. and Aitken, Robert and Alouf, J.E and Boulnois, G. and Falmagne, P. and Fehrenbach, F. and Montecucco, C. and Piemont, Y. and Rappuoli, R. and Wadstrom, Torkel and Witholt, B., eds. Bacterial Protein Toxins - Sixth European Workshop. Gustav Fischer Verlag pp. 206-207. ISBN 3-437-11535-9. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Hirst, Timothy R. and Nashar, Toufic O. and Eaglestone, Simon S. and Lencer, W.I. and Webb, Helen M. and Yu, J. (1994) Bacterial and Host Interactions During the Biogenesis, Toxicity and Immunogenicity of Escherichia-Coli Heat-Labile Enterotoxin. In: Biochemical Society Transactions. Portland Press pp. 306-309. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Yu, J. and Findlay, G. and Webb, Helen M. and McLaughlin, Stephen H. and Hirst, Timothy R. (1994) Proteins Involved in the Catalysis of Enterotoxin Formation. In: Freer, J. and Aitken, Robert and Alouf, J.E and Boulnois, G. and Falmagne, P. and Fehrenbach, F. and Montecucco, C. and Piemont, Y. and Rappuoli, R. and Wadstrom, Torkel and Witholt, B., eds. Bacterial Protein Toxins-Sixth European Workshop. Gustav Fischer Verlag pp. 173-182. ISBN 3-437-11535-9. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Aitken, Robert and Hirst, Timothy R. (1993) Recombinant enterotoxins as vaccines against escherichia-coli-mediated diarrhea. In: International Conf on Vaccines for Enteric Diseases, APR 13-15, 1992, Cambridge, England. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Findlay, G. and Hirst, Timothy R. (1993) The Role of DSBA in Enterotoxin Biogenesis and Cell Viability. In: Freer, J. and Aitken, Robert and Alouf, J.E and Boulnois, G. and Falmagne, P. and Fehrenbach, F. and Montecucco, C. and Piemont, Y. and Rappuoli, R. and Wadstrom, Torkel and Witholt, B., eds. Bacterial Protein Toxins - Sixth European Workshop. Gustav Fischer Verlag pp. 212-213. ISBN 3-437-11535-9. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
