David-Cordonnier, Marie-Helene and Casely-Hayford, Maxwell A. and Kouach, Mostafa and Briand, Gilbert and Patterson, Laurence H. and Bailly, Christian and Searcey, Mark (2006) Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide. ChemBioChem, 7 (11). pp. 1658-1661.
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In this study we show that the four diastereomers of the azinomycin epoxide (1) have different sequence selectivities, while the natural product appears to exert its effects through reversible N7 alkylation of guanine followed by irreversible depurination (see scheme).
|Projects:|| Study of the mechanism of action of the azinomycin epoxide|
|Uncontrolled keywords:||antitumor agents, azinomycin, depurination, DNA cleavage, natural products|
|Divisions:||Faculties > Science Technology and Medical Studies > Medway School of Pharmacy|
|Depositing User:||Maxwell Casely-Hayford|
|Date Deposited:||23 Sep 2008 14:32|
|Last Modified:||14 Jan 2010 14:35|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/9475 (The current URI for this page, for reference purposes)|
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