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Factors affecting the release of nifedipine from a Swellable elementary osmotic pump

Nokhodchi, Ali, Momin, Mohammed N., Shokri, Javad, Shahsavari, Mahbobeh, Rashaidi, Parinaz Ahmad (2008) Factors affecting the release of nifedipine from a Swellable elementary osmotic pump. Drug Delivery, 15 (1). 43 -48. ISSN 1071-7544. (doi:10.1080/10717540701829028) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:9319)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1080/10717540701829028

Abstract

Oral osmotic devices including an elementary osmotic pump (EOP) are efficient systems for the delivery of drugs with high/moderately water-solublility. In this study we designed a new type of EOP for the efficient delivery of poorly water-soluble and practically insoluble drugs. In this system, called swellable elementary osmotic pump (SEOP), drug is released from the delivery orifice in the form of a very fine dispersion of drug in gel which is ready for dissolution and absorption. Factors affecting the release of drug from the SEOP containing a poorly water-soluble drug, nifedipine, were explored extensively. To this end, effect of swelling and wetting agents, orifice size, concentration of osmotic agent, and hydrophobic plasticizer were investigated. Interestingly, in the absence or low concentration of a hydrophobic plasticizer (caster oil), the osmotic devices did not retain their integrity in dissolution media. Caster oil in concentration of > 1% was necessary for tablets to retain their integrity during dissolution process. A zero-order release kinetics for nifedipine was achieved following the effective optimization of the concentrations of swelling agent, osmotic agent, wetting agent, and also size of orifice and membrane thickness in SEOP. The zero-order release lasted for 10 hr at pH 6.8 dissolution medium. The designed SEOP is suggested as an efficient controlled delivery system for oral delivery of a poorly water soluble drug such as nifedipine.

Item Type: Article
DOI/Identification number: 10.1080/10717540701829028
Uncontrolled keywords: nifedipine; swellable elementary osmotic pump; zero-order release; orifice size; plasticizer
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Ali Nokhodchi
Date Deposited: 14 Mar 2009 12:34 UTC
Last Modified: 16 Nov 2021 09:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/9319 (The current URI for this page, for reference purposes)

University of Kent Author Information

Nokhodchi, Ali.

Creator's ORCID:
CReDIT Contributor Roles:

Momin, Mohammed N..

Creator's ORCID: https://orcid.org/0000-0003-0904-4424
CReDIT Contributor Roles:
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