Truncated azinomycin analogues intercalated into DNA

Casely-Hayford, Maxwell A. and Pors, Klaus and Patterson, Laurence H. and Gernera, Clive and Neidle, Stephen and Searcey, Mark (2005) Truncated azinomycin analogues intercalated into DNA. Bioorganic & Medicinal Chemistry Letters, 15 (3). 653-656. ISSN 0960-894X. (The full text of this publication is not available from this repository)

The full text of this publication is not available from this repository. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/j.bmcl.2004.11.037

Abstract

The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding.

Item Type: Article
Projects: [50] Azinomycins
Uncontrolled keywords: Azinomycin; Intercalation; DNA unwinding; Synthesis; Analogues
Subjects: Q Science
Q Science > QD Chemistry
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Maxwell Casely-Hayford
Date Deposited: 18 Nov 2008 13:00
Last Modified: 22 Apr 2014 14:35
Resource URI: http://kar.kent.ac.uk/id/eprint/9224 (The current URI for this page, for reference purposes)
  • Depositors only (login required):