Casely-Hayford, Maxwell A. and Pors, K. and Patterson, L.H. and Gernera, C. and Neidle, S. and Searcey, M. (2005) Truncated azinomycin analogues intercalated into DNA. Bioorganic and Medicinal Chemistry Letters, 15 (3). 653-656. ISSN 0960-894X.
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| Official URL http://10.1016/j.bmcl.2004.11.037 |
Abstract
The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding.
| Item Type: | Article |
|---|---|
| Projects: | [50] Azinomycins |
| Uncontrolled keywords: | Azinomycin; Intercalation; DNA unwinding; Synthesis; Analogues |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | Faculties > Science Technology and Medical Studies > Medway School of Pharmacy |
| Depositing User: | Maxwell Casely-Hayford |
| Date Deposited: | 18 Nov 2008 13:00 |
| Last Modified: | 11 May 2012 14:31 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/9224 (The current URI for this page, for reference purposes) |
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