Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision

Guler, Ali D. and Ecker, Jennifer L. and Lall, Gurprit S. and Haq, Shafiqul and Altimus, Cara M. and Liao, Hsi-wen and Barnard, Alun R. and Cahill, Hugh and Badea, Tudor C. and Zhao, Haiqing and Hankins, Mark W. and Berson, David M. and Lucas, Robert J. and Yau, King-Wai and Hattar, Samer (2008) Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. Nature, 453 (7191). pp. 102-105. ISSN 0028-0836 . (The full text of this publication is not available from this repository)

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Rod and cone photoreceptors detect light and relay this information through a multisynaptic pathway to the brain by means of retinal ganglion cells (RGCs). These retinal outputs support not only pattern vision but also non-image-forming (NIF) functions, which include circadian photoentrainment and pupillary light reflex (PLR). In mammals, NIF functions are mediated by rods, cones and the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). Rod-cone photoreceptors and ipRGCs are complementary in signalling light intensity for NIF functions. The ipRGCs, in addition to being directly photosensitive, also receive synaptic input from rod-cone networks. To determine how the ipRGCs relay rod-cone light information for both image-forming and non-image-forming functions, we genetically ablated ipRGCs in mice. Here we show that animals lacking ipRGCs retain pattern vision but have deficits in both PLR and circadian photoentrainment that are more extensive than those observed in melanopsin knockouts. The defects in PLR and photoentrainment resemble those observed in animals that lack phototransduction in all three photoreceptor classes. These results indicate that light signals for irradiance detection are dissociated from pattern vision at the retinal ganglion cell level, and animals that cannot detect light for NIF functions are still capable of image formation.

Item Type: Article
Additional information: I am Joint first author on this manuscript.
Uncontrolled keywords: Animals Brain/cytology/metabolism Circadian Rhythm/physiology/radiation effects Cones (Retina)/*metabolism Cues Electroretinography Light Mice Mice, Inbred C57BL Mice, Knockout Motor Activity/physiology Opsin/deficiency/genetics/*metabolism Pupil/physiology/radiation effects Reflex/physiology/radiation effects Retinal Ganglion Cells/*cytology/*metabolism Rods (Retina)/*metabolism Vision/*physiology/radiation effects Visual Acuity/physiology
Subjects: Q Science
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology (Living systems)
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Gurprit Lall
Date Deposited: 14 Mar 2009 11:37
Last Modified: 25 Apr 2014 12:16
Resource URI: (The current URI for this page, for reference purposes)
ORCiD (Guler, Ali D.):
ORCiD (Ecker, Jennifer L.):
ORCiD (Lall, Gurprit S.):
ORCiD (Haq, Shafiqul):
ORCiD (Altimus, Cara M.):
ORCiD (Liao, Hsi-wen):
ORCiD (Barnard, Alun R.):
ORCiD (Cahill, Hugh):
ORCiD (Badea, Tudor C.):
ORCiD (Zhao, Haiqing):
ORCiD (Hankins, Mark W.):
ORCiD (Berson, David M.):
ORCiD (Lucas, Robert J.):
ORCiD (Yau, King-Wai):
ORCiD (Hattar, Samer):
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