Sha, N. and Vannucci, M. and Tadesse, M.G. and Brown, P.J. and Dragoni, I. and Davies, N. and Roberts, T.C. and Contestabile, A. and Salmon, M. and Buckley, C. and Falcaiani, F. (2004) Bayesian variable selection in multinomial probit models to identify molecular signatures of disease stage. BIOMETRICS, 60 (3). pp. 812-819. ISSN 0006-341X.
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Here we focus on discrimination problems where the number of predictors substantially exceeds the sample size and we propose a Bayesian variable selection approach to multinomial probit models. Our method makes use of mixture priors and Markov chain Monte Carlo techniques to select sets of variables that differ among the classes. We apply our methodology to a problem in functional genomics using gene expression profiling data. The aim of the analysis is to identify molecular signatures that characterize two different stages of rheumatoid arthritis.
|Subjects:||Q Science > QA Mathematics (inc Computing science) > QA276 Mathematical statistics|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Mathematics Statistics and Actuarial Science|
|Depositing User:||Philip J Brown|
|Date Deposited:||01 Oct 2008 14:36|
|Last Modified:||14 Jan 2010 14:30|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/8146 (The current URI for this page, for reference purposes)|
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