Emerging epidemic diseases of frogs in Britain are dependent on the source of ranavirus agent and the route of exposure

Cunningham, A.A. and Hyatt, A.D. and Russell, P. and Bennett, P.M. (2007) Emerging epidemic diseases of frogs in Britain are dependent on the source of ranavirus agent and the route of exposure. Epidemiology and Infection, 135 (7). pp. 1200-1212. ISSN 0950-2688. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1017/S0950268806007679

Abstract

A series of transmission studies was conducted to investigate the aetiology, or aetiologies, of emerging fatal epidemic disease syndromes affecting the common frog (Rana temporaria) in Britain. The syndromes, characterized by skin ulceration or systemic haemorrhages, were induced upon exposure to lesion homogenates or cultured ranavirus. The re-isolation of ranavirus frorn experimentally affected frogs fulfilled Koch's postulates. Aeromonas hydrophila, previously associated with similar lesions, was not significant to disease development. Unexpectedly, disease outcomes were influenced by both the source of agent and the route of exposure, indicating that different ranaviruses with different tissue tropisms and pathogeneses (possibly similar to quasi-species in RNA virus populations) are circulating in the British common frog population. Our findings confirm that ranavirus disease has emerged as an important cause of amphibian mortality in Britain.

Item Type: Article
Additional information: ISI Document Delivery No.: 231JB Times Cited: 0 Cited Reference Count: 40 Cunningham, A. A. Hyatt, A. D. Russell, P. Bennett, P. M.
Uncontrolled keywords: HUMAN-IMMUNODEFICIENCY-VIRUS AMPHIBIAN POPULATION DECLINES ANTIMICROBIAL PEPTIDES RAPID EVOLUTION RANA-TEMPORARIA RNA VIRUSES BK VIRUS ESCAPE IRIDOVIRUSES MORTALITY
Subjects: G Geography. Anthropology. Recreation > GN Anthropology
Divisions: Faculties > Social Sciences > School of Anthropology and Conservation > DICE (Durrell Institute of Conservation and Ecology)
Depositing User: C.G.W.G. van-de-Benderskum
Date Deposited: 26 Jun 2008 13:34
Last Modified: 14 Jan 2010 14:27
Resource URI: http://kar.kent.ac.uk/id/eprint/7506 (The current URI for this page, for reference purposes)
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