Alternate signalling pathways from the interleukin-2 receptor

Ellery, Jonathan M. and Nicholls, Peter J. (2002) Alternate signalling pathways from the interleukin-2 receptor. Cytokine & Growth Factor Reviews, 13 (1). pp. 27-40. ISSN 1359-6101. (The full text of this publication is not available from this repository)

The full text of this publication is not available from this repository. (Contact us about this Publication)
Official URL


Interleukin-2 (IL-2) plays a major role in the proliferation of cell populations during an immune reaction. The beta(c) and gamma(c) subunits of the IL-2 receptor (IL-2R) are sufficient and necessary for signal transduction. Despite lacking known catalytic domains, receptor engagement leads to the activation of a diverse array protein tyrosine kinases (PTKs). In resting or anergised T cells, Jak3 is not activated. Signals arising from the PROX domain of the gamma(c) subunit activate p56(lck) (lck) leading to the induction of anti-apoptotic mechanisms. When Jak3 is activated, in primed T cells, other PTKs predominantly mediate the induction of anti-apoptotic mechanisms and drive cellular proliferation. This review intends to suggest a role for these differences within the context of the immune system.

Item Type: Article
Additional information: 1359-6101 (Print) Journal Article Review
Uncontrolled keywords: interleukin-2 receptor (IL-2R); Jak3; phosphatidylinositol 3 kinase (PI3K) Dimerization Humans Interleukin-2/metabolism Janus Kinase 3 Mitogen-Activated Protein Kinase 1/metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases/metabolism Models, Biological Protein-Tyrosine Kinases/metabolism Receptors, Antigen, T-Cell/metabolism Receptors, Interleukin-2/*metabolism *Signal Transduction Transcription, Genetic
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Peter Nicholls
Date Deposited: 17 Sep 2008 12:12
Last Modified: 03 Jun 2014 08:40
Resource URI: (The current URI for this page, for reference purposes)
  • Depositors only (login required):