Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032

Riedlinger, Julia and Reicke, Andreas and Zahner, Hans and Krismer, B. and Bull, Alan T. and Maldonado, Luis A. and Ward, Alan C. and Goodfellow, Michael and Bister, Bojan and Bischoff, Daniel and Sussmuth, Roderich D. and Fiedler, Hans-Peter (2004) Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032. Journal of Antibiotics, 57 (4). pp. 271-279. ISSN 0021-8820. (The full text of this publication is not available from this repository)

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Abstract

A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.

Item Type: Article
Additional information: Article 823WD English Times Cited:28 Cited References Count:23
Uncontrolled keywords: antibiotics, tetronic acid, structure elucidation, abyssomicins, Verrucosispora
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 03 Oct 2008 15:24
Last Modified: 29 Apr 2014 08:30
Resource URI: http://kar.kent.ac.uk/id/eprint/7347 (The current URI for this page, for reference purposes)
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