Bringmann, G. and Lang, G. and Maksimenka, K. and Hamm, A. and Gulder, T.A.M. and Dieter, A. and Bull, A.T. and Stach, J.E.M. and Kocher, N. and Muller, W.E.G. and Fiedler, H.P. (2005) Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14. PHYTOCHEMISTRY, 66 (11). pp. 1366-1373. ISSN 0031-9422 .
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The new, highly oxygenated angucyclinone gephyromycin was isolated from an extract of a Streptomyces griseus strain. Its unprecedented ether-bridged structure was elucidated by NMR methods and substantiated by single crystal X-ray analysis. The absolute configuration was evidenced by quantum chemical CD calculations. Gephyromycin exhibits glutaminergic activity towards neuronal cells. Furthermore, the known compounds fridamycin E and dehydrorabelomycin were identified. (c) 2005 Elsevier Ltd. All rights reserved.
|Additional information:||Article 947FM English Times Cited:2 Cited References Count:29|
|Uncontrolled keywords:||Streptomyces angucyclinones natural products secondary metabolites glutaminergic activity circular dichroism (CD) quantum chemical CD calculations X-ray structure analysis ANTIBIOTICS URDAMYCINS MECHANISMS FLUPIRTINE|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group|
|Depositing User:||Sue Davies|
|Date Deposited:||05 Sep 2008 15:44|
|Last Modified:||14 Jan 2010 14:26|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/7345 (The current URI for this page, for reference purposes)|
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