Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora

Fiedler, Hans-Peter and Bruntner, Christina and Riedlinger, Julia and Bull, Alan T. and Knutsen, Gjert and Goodfellow, Michael and Jones, Amanda L. and Maldonado, Luis A. and Pathom-aree, Wasu and Beil, Winfried and Schneider, Kathrin and Keller, Simone and Sussmuth, Roderich D. (2008) Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora. Journal of Antibiotics, 61 (3). pp. 158-163. ISSN 0021-8820 . (The full text of this publication is not available from this repository)

The full text of this publication is not available from this repository. (Contact us about this Publication)
Official URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=...

Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

Item Type: Article
Additional information: Article 287UL English Times Cited:0 Cited References Count:15
Uncontrolled keywords: aminofuran antibiotics antitumor activity marine actinomycetes Verrucosispora physico-chemical properties proximicin A proximicin B proximicin C
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 14 Mar 2009 10:17
Last Modified: 01 May 2014 15:14
Resource URI: http://kar.kent.ac.uk/id/eprint/7332 (The current URI for this page, for reference purposes)
  • Depositors only (login required):