Hayes, N.V.L. and Gullick, W.J. (2008) The Neuregulin family of genes and their multiple splice variants in breast cancer. Journal of Mammary Gland Biology and Neoplasia, 13 (2). pp. 205-214. ISSN 1083-3021 .
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The Neuregulin family consists of four genes, NRG1-4 which can each encode products containing a domain related to the epidermal growth factor family of ligands. Each gene is subject to complex control of transcription and to splicing of their mRNA product to give many variant proteins. These do not contain secretory sequences but some, through their transmembrane sequence, are routed via the Golgi where they are glycosylated, to the cell surface. Here they may be released by regulated proteolysis to act as soluble proteins which can interact and activate members of the EGF receptor family of receptor tyrosine kinases. Other splice variants do not encode transmembrane sequences and these are found either in the cytoplasm or, if they encode a nuclear localisation sequence, in distinct compartments in the nucleoplasm. It has been shown that the variants containing a full EGF domain can act as receptor agonists but the function of the cytoplasmic and nuclear products is unknown as yet.
|Uncontrolled keywords:||neuregulin; heregulin; splicing; breast cancer|
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group|
|Depositing User:||Bill Gullick|
|Date Deposited:||13 Feb 2009 11:49|
|Last Modified:||05 Sep 2011 23:57|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/7276 (The current URI for this page, for reference purposes)|
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