Morgan, T.D and Beezer, A.E and Mitchell, J.C and Bunch, A.W (2001) A microcalorimetric comparison of the anti-Streptococcus mutans efficacy of plant extracts and antimicrobial agents in oral hygiene formulations. J Appl Microbiol, 90 (1). pp. 53-58. ISSN 1364-5072 .
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AIMS: This study aimed to evaluate the efficacy of 'natural' putative antimicrobial agents against Streptococcus mutans and to compare these with synthetic agents using the flow microcalorimeter. Streptococcus mutans is one of the oral pathogens responsible for dental caries. METHODS AND RESULTS: Traditional microbiological techniques are invasive and destructive unlike flow microcalorimetry. This rapid technique was used to continuously monitor the power output (bioactivity) of Strep. mutans with reproducibility, precision and accuracy. The antibacterial agents found in oral hygiene products and all the natural agents tested showed anti-Strep. mutans ability. CONCLUSION: In this study microcalorimetry identified agents that had a biological effect and quantified the rate of kill achieved enabling four broad categories of antimicrobial agent to be defined. SIGNIFICANCE AND IMPACT OF THE STUDY: Microcalorimetric data are a better indication of antimicrobial efficacy than merely determining concentrations at which an antimicrobial agent is bacteriostatic or bactericidal.
|Additional information:||1364-5072 (Print) Comparative Study Journal Article Research Support, Non-U.S. Gov't|
|Uncontrolled keywords:||Anti-Bacterial Agents/*pharmacology Calorimetry Chemistry, Pharmaceutical Dental Caries/microbiology/prevention & control Dose-Response Relationship, Drug Oral Hygiene/*methods Plant Extracts/*pharmacology Streptococcus mutans/*drug effects/*growth & development|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group|
|Depositing User:||Sue Davies|
|Date Deposited:||29 Oct 2008 18:35|
|Last Modified:||14 Jan 2010 14:26|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/7111 (The current URI for this page, for reference purposes)|
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