Stebbings, L.A. and Todman, M.G. and Phillips, R. and Greer, C.E. and Tam, J. and Phelan, P. and Jacobs, K. and Bacon, J.P. and Davies, J.A. (2002) Gap junctions in Drosophila: developmental expression of the entire innexin gene family. Mechanisms of Development, 113 (2). pp. 197-205. ISSN 0925-4773 .
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Invertebrate gap junctions are composed of proteins called innexins and eight innexin encoding loci have been identified in the now complete genome sequence of Drosophila melanogaster. The intercellular channels formed by these proteins are multimeric and previous studies have shown that, in a heterologous expression system, homo- and hetero-oligomeric channels can form, each combination possessing different gating characteristics. Here we demonstrate that the innexins exhibit complex overlapping expression patterns during oogenesis, embryogenesis, imaginal wing disc development and central nervous system development and show that only certain combinations of innexin oligomerization are possible in vivo. This work forms an essential basis for future studies of innexin interactions in Drosophila and outlines the potential extent of gap-junction involvement in development.
|Additional information:||0925-4773 (Print) Journal Article Research Support, Non-U.S. Gov't|
|Uncontrolled keywords:||Amino Acid Sequence Animals Central Nervous System/embryology Chromosomes/ultrastructure Connexins/*biosynthesis DNA, Complementary/metabolism Drosophila Proteins/*biosynthesis Drosophila melanogaster Gene Expression In Situ Hybridization Models, Genetic Molecular Sequence Data Phylogeny RNA, Messenger/metabolism Retina/embryology Sequence Homology, Amino Acid Wing/embryology|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Cell & Developmental Biology Group|
|Depositing User:||Pauline Phelan|
|Date Deposited:||09 Sep 2008 18:15|
|Last Modified:||14 Jan 2010 14:25|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/6605 (The current URI for this page, for reference purposes)|
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