Phelan, P. and Starich, T.A. (2001) Innexins get into the Gap. Bioessays, 23 (5). pp. 388-396. ISSN 0265-9247 .
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Connexins were first identified in the 1970s as the molecular components of vertebrate gap junctions. Since then a large literature has accumulated on the cell and molecular biology of this multi-gene family culminating recently in the findings that connexin mutations are implicated in a variety of human diseases. Over two decades, the terms "connexin" and "gap junction" had become almost synonymous. In the last few years a second family of gap-junction genes, the innexins, has emerged. These have been shown to form intercellular channels in genetically tractable invertebrate organisms such as Drosophila melanogaster and Caenorhabditis elegans. The completed genomic sequences for the fly and worm allow identification of the full complement of innexin genes in these two organisms and provide valuable resources for genetic analyses of gap junction function.
|Additional information:||0265-9247 (Print) Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review|
|Uncontrolled keywords:||Animals Caenorhabditis elegans/genetics/physiology Connexins/genetics/*physiology Drosophila melanogaster/genetics/physiology Gap Junctions/*physiology Genes, Helminth Genes, Insect Humans Invertebrates Ion Channels/genetics/physiology Mutation|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Cell & Developmental Biology Group
Faculties > Science Technology and Medical Studies > School of Biosciences
|Depositing User:||Pauline Phelan|
|Date Deposited:||30 Oct 2008 19:56|
|Last Modified:||14 Jan 2010 14:25|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/6604 (The current URI for this page, for reference purposes)|
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