Phelan, P. (2005) Innexins: members of an evolutionarily conserved family of gap-junction proteins. Biochim Biophys Acta, 1711 (2). pp. 225-245. ISSN 0005-2736 .
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Gap junctions are clusters of intercellular channels that provide cells, in all metazoan organisms, with a means of communicating directly with their neighbours. Surprisingly, two gene families have evolved to fulfil this fundamental, and highly conserved, function. In vertebrates, gap junctions are assembled from a large family of connexin proteins. Innexins were originally characterized as the structural components of gap junctions in Drosophila, an arthropod, and the nematode Caenorhabditis elegans. Since then, innexin homologues have been identified in representatives of the other major invertebrate phyla and in insect-associated viruses. Intriguingly, functional innexin homologues have also been found in vertebrate genomes. These studies have informed our understanding of the molecular evolution of gap junctions and have greatly expanded the numbers of model systems available for functional studies. Genetic manipulation of innexin function in relatively simple cellular systems should speed progress not only in defining the importance of gap junctions in a variety of biological processes but also in elucidating the mechanisms by which they act.
|Additional information:||0006-3002 (Print) Journal Article Research Support, Non-U.S. Gov't Review|
|Uncontrolled keywords:||Amino Acid Sequence Animals Caenorhabditis elegans/growth & development Caenorhabditis elegans Proteins/genetics Connexins/*genetics/physiology Drosophila Proteins/genetics/physiology Drosophila melanogaster/growth & development Evolution Gap Junctions/*genetics/physiology Humans Ion Channels/physiology Membrane Proteins/genetics/physiology Molecular Sequence Data Mutation Nerve Tissue Proteins/genetics/physiology Phenotype Sequence Alignment|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Cell & Developmental Biology Group|
|Depositing User:||Pauline Phelan|
|Date Deposited:||05 Sep 2008 10:38|
|Last Modified:||14 Jan 2010 14:25|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/6603 (The current URI for this page, for reference purposes)|
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