Sheth, C.C. and Mogensen, E.G. and Fu, M.S. and Blomfield, I.C. and Muhlschlegel, F.A. (2008) Candida albicans HSP12 is co-regulated by physiological CO2 and pH. Fungal Genetics and Biology, 45 (7). pp. 1075-1080. ISSN 1087-1845 .
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Global transcriptional analysis of Candida albicans exposed to elevated ambient CO(2) revealed a statistically significant differential regulation of 14 genes. Subsequent RNA hybridisation analysis of one gene, HSP12, confirmed CO(2)-regulation via a cAMP-dependent mechanism. Additionally, Northern analyses and gel mobility shift assays demonstrate the co-regulation of HSP12 by environmental pH via a Rim101-dependent mechanism.
|Additional information:||1096-0937 (Electronic) Journal article|
|Uncontrolled keywords:||Candida albicans; CO2; microarray; HSP12; EMSA; pH; transcriptional regulation|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group|
|Depositing User:||F.A. Muhlschlegel|
|Date Deposited:||13 Mar 2009 10:37|
|Last Modified:||14 Jan 2010 14:23|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/6198 (The current URI for this page, for reference purposes)|
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