Effect of the Growth Medium on the In Vitro Antifungal Activity of Micafungin (FK-463) against Clinical Isolates of Candida Dubliniensis

Muller, F.M. and Kurzai, O. and Hacker, J. and Frosch, M. and Muhlschlegel, F.A. (2001) Effect of the Growth Medium on the In Vitro Antifungal Activity of Micafungin (FK-463) against Clinical Isolates of Candida Dubliniensis. Journal of Antimicrobial Chemotherapy, 48 (5). pp. 713-715. ISSN 0305-7453. (The full text of this publication is not available from this repository)

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Abstract

Micafungin (FK-463), a member of the new candin family of antifungal agents, was highly active against clinical isolates of Candida albicans and Candida dubliniensis. The in vitro activity of micafungin suggested that it was more potent than fluconazole, flucytosine, amphotericin B or voriconazole against C. albicans, and comparable or moderately less effective against C. dubliniensis isolates when high-resolution medium (HR) was used. Lower MICs of micafungin were recorded when RPMI 2% or AM3 2% media were used, indicating an influence of the growth medium on the MIC.

Item Type: Article
Additional information: 0305-7453 (Print) Comparative Study Journal Article Research Support, Non-U.S. Gov't
Uncontrolled keywords: Antibiotics, Antifungal/*pharmacology Candida/*drug effects/*growth & development/isolation & purification Candida albicans/drug effects/growth & development/isolation & purification Culture Media/pharmacology Echinocandins Humans Lipoproteins/*pharmacology Peptides, Cyclic/*pharmacology
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: F.A.M. Muhlschlegel
Date Deposited: 28 Oct 2008 19:05
Last Modified: 28 Mar 2012 10:45
Resource URI: http://kar.kent.ac.uk/id/eprint/6196 (The current URI for this page, for reference purposes)
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