FXII levels, FXIIa-like activities and kallikrein activities in normal subjects and patients undergoing cardiac surgery

Wendel, H.P. and Jones, D.W. and Gallimore, M.J. (1999) FXII levels, FXIIa-like activities and kallikrein activities in normal subjects and patients undergoing cardiac surgery. In: 15th International Conference on Kinins (KININ 98), OCT 19-24, 1998, Nara, Japan. (The full text of this publication is not available from this repository)

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Abstract

A new chromogenic peptide substrate assay kit was used to measure factor XII (FXII) levels in plasma samples from 115 male patients with heart disease awaiting cardiac surgery, 40 age-matched normal healthy male blood donors and 20 patients before, during and after cardiopulmonary bypass surgery (CPB). Kallikrein-like and FXIIa-like activities were also determined in the CPB patient group. FXII levels were significantly lower (p = 0.0049) in the heart disease patients awaiting surgery when compared with values for the healthy donors and 13 patients (11.3%) had FXII levels below 50% compared with 1 normal donor (2.5%). During CPB significant decreases in FXII levels and significant increases in FXIIa-like and kallikrein-like activities were found indicating activation of the FXII-plasma kallikrein pathway during CPB.

Item Type: Conference or workshop item (Paper)
Additional information: 0162-3109 (Print) Proceedings Paper
Uncontrolled keywords: Adult Aged *Coronary Artery Bypass Enzyme Activation Factor XII/*metabolism Factor XIIa/*metabolism Humans Kallikreins/*metabolism Male Middle Aged Perioperative Care
Subjects: Q Science
Q Science > QR Microbiology > QR180 Immunology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: D Wynne Jones
Date Deposited: 16 Mar 2009 18:22
Last Modified: 14 Jan 2010 14:21
Resource URI: http://kar.kent.ac.uk/id/eprint/5598 (The current URI for this page, for reference purposes)
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