O'Sullivan, J.M. and Davenport, J.B. and Tuite, M.F. (2001) Codon Reassignment and the Evolving Genetic Code: Problems and Pitfalls in Post-genome Analysis. Trends in Genetics, 17 (1). pp. 20-22. ISSN 0168-9525.
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The in silico translation of open reading frames, using the 'universal genetic code', must be approached with caution. The uncovering of a number of codon reassignments in nuclear and organellar genomes highlights the importance of experimentally confirming the assignments of all 64 codons for the species whose genome is under investigation. Such alterations to codon meaning also suggest that the genetic code is not 'frozen' and continues to evolve.
|Additional information:||0168-9525 (Print) Journal Article|
|Uncontrolled keywords:||*Codon *Genetic Code *Genome, Bacterial *Genome, Fungal RNA Editing|
|Subjects:||Q Science > QR Microbiology|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||Mick Tuite|
|Date Deposited:||28 Oct 2008 18:35|
|Last Modified:||14 Jan 2010 14:20|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/5464 (The current URI for this page, for reference purposes)|
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