Edwards, Alison A. and Sanjayan, Gangadhar J. and Haschisu, Shuji and Tranter, George E. and Fleet, George W.J. (2006) A novel series of oligomers from 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans stereochemistry. Tetrahedron, 62 (33). pp. 7718-7725. ISSN 0040-4020.
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Two tetrahydrofuran-based g-amino acids [2,4-cis and 2,4-trans] were subjected to iterative peptide-coupling procedures to afford dimeric, tetrameric and hexameric carbopeptoids in good yield. These homooligomers were prepared for secondary structural study—to ascertain the conformational preference inherent in the monomer units. The L-xylo oligomers were protected with triethylsilyl ethers to increase the range of solvents suitable for structural investigation. Initial secondary structure data indicate the presence of hydrogen-bonded conformations in the L-ribo series.
|Divisions:||Faculties > Science Technology and Medical Studies > Medway School of Pharmacy|
|Depositing User:||Alison Edwards|
|Date Deposited:||02 Sep 2008 06:40|
|Last Modified:||05 Sep 2011 23:40|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/4897 (The current URI for this page, for reference purposes)|
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