Mayes, Benjamin A. and Stetz, Rebecca J.E. and Watterson, Mark P. and Edwards, Alison A. and Ansell, Christopher W.G. and Tranter, George E. and Fleet, George W.J. (2004) Towards hydroxylated nylon 6: linear and cyclic oligomers from a protected 6-amino-6-deoxy-DD -galactonate––a novel class of carbopeptoid-cyclodextrin (CPCD). Tetrahedron: Asymmetry, 15 (4). pp. 627-638. ISSN 0957-4166 .
Restricted to Repository staff only
| Contact us about this Publication
Circular dichroism studies on a series of linear oligomers derived from a protected 6-amino-6-deoxy-D-galactonate (an epsilon-amino acid) indicated a predisposition to form a rigid structure in solution, which is comparable to a beta-sheet composed of L-amino acids; in contrast, a diastereomeric allonate series provided no evidence for secondary structure. A linear tetramer was cyclised to a 28-membered ring lactam in modest yield, which on deprotection formed a class of macrocycle with structural features of both a cyclic peptide and a cyclodextrin.
Q Science > QD Chemistry
|Divisions:||Faculties > Science Technology and Medical Studies > Medway School of Pharmacy|
|Depositing User:||Alison Edwards|
|Date Deposited:||05 Sep 2008 12:56|
|Last Modified:||28 May 2012 10:46|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/4886 (The current URI for this page, for reference purposes)|
- Depositors only (login required):