Calcineurin Antagonists Differentially Affect Mediator Secretion, p38 Mitogen Activated Protein Kinase and Extracellular Signal Regulated Kinases from Immunologically Activated Human Basophils.

Plath, K.E.S. and Grabbe, Jurgen and Gibbs, Bernhard F (2003) Calcineurin Antagonists Differentially Affect Mediator Secretion, p38 Mitogen Activated Protein Kinase and Extracellular Signal Regulated Kinases from Immunologically Activated Human Basophils. Clinical and Experimental Allergy, 33 (3). pp. 342-350. ISSN 0954-7894 . (The full text of this publication is not available from this repository)

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Abstract

Background Basophils participate in allergic diseases by invading affected tissues and secreting histamine, leukotriene (LT)C4, IL-4 and IL-13 following FcepsilonRI cross-linking. A reduction of basophil mediator production is therefore of considerable therapeutical interest. Macrolactam derivatives, which inhibit calcineurin activation, may be candidates for antiallergic therapy as they reduce both symptoms of inflammatory skin disease in animal models and mast cell degranulation.

Item Type: Article
Subjects: R Medicine
Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Bernhard F. Gibbs
Date Deposited: 05 Sep 2008 12:50
Last Modified: 07 Jul 2014 13:59
Resource URI: http://kar.kent.ac.uk/id/eprint/4813 (The current URI for this page, for reference purposes)
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