Plath, K.E.S., Grabbe, Jurgen, Gibbs, Bernhard F (2003) Calcineurin Antagonists Differentially Affect Mediator Secretion, p38 Mitogen Activated Protein Kinase and Extracellular Signal Regulated Kinases from Immunologically Activated Human Basophils. Clinical and Experimental Allergy, 33 (3). pp. 342-350. ISSN 0954-7894. (doi:10.1046/j.1365-2222.2003.01708.x) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:4813)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://doi.org/10.1046/j.1365-2222.2003.01708.x |
Abstract
Background Basophils participate in allergic diseases by invading affected tissues and secreting histamine, leukotriene (LT)C4, IL-4 and IL-13 following FcepsilonRI cross-linking. A reduction of basophil mediator production is therefore of considerable therapeutical interest. Macrolactam derivatives, which inhibit calcineurin activation, may be candidates for antiallergic therapy as they reduce both symptoms of inflammatory skin disease in animal models and mast cell degranulation.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1046/j.1365-2222.2003.01708.x |
| Subjects: |
R Medicine Q Science > QR Microbiology > QR180 Immunology |
| Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
| Depositing User: | Bernhard F. Gibbs |
| Date Deposited: | 05 Sep 2008 12:50 UTC |
| Last Modified: | 09 Mar 2023 11:29 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/4813 (The current URI for this page, for reference purposes) |
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