Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin-4

Aumüller, E. and Schramm, G. and Gronow, A. and Brehm, K. and Gibbs, B.F. and Doenhoff, M.J. and Haas, H. (2004) Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin-4. Parasite Immunology, 26 (10). pp. 387-395. ISSN 0141-9838. (The full text of this publication is not available from this repository)

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Abstract

Infections with parasitic helminths are associated with a T helper 2 (Th2) immune response and IgE production. The underlying mechanism, however, is only partially understood. Recently we have isolated a protein from extracts of Schistosoma mansoni eggs that triggers human basophils from non-sensitized donors to release interleukin-4 (IL-4), the key cytokine of a Th2 response. We called this protein IPSE (for IL-4-inducing principle from Schistosoma mansoni eggs). Supposing that IPSE-like IL-4-inducing activities might be a general principle shared among different helminth species, we investigated extracts from the cestode E. multilocularis for its effect on human basophils. Our results showed that extracts from metacestodes of E. multilocularis cause basophil degranulation, as well as the secretion of histamine, IL-4 and IL-13, in a dose-dependent manner. IgE stripping and resensitization of basophils indicated that the mechanism of IL-4 induction requires the presence of IgE on the cells. Since analogous properties have been demonstrated earlier for IPSE, we think that S. mansoni and E. multilocularis may induce a Th2 response in their hosts via a related mechanism, namely, by the induction of IL-4 release from basophils.

Item Type: Article
Uncontrolled keywords: Echinococcus multilocularis; human basophils; interleukin-4
Subjects: R Medicine
Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Bernhard F. Gibbs
Date Deposited: 08 Sep 2008 14:51
Last Modified: 14 Jan 2010 14:17
Resource URI: http://kar.kent.ac.uk/id/eprint/4807 (The current URI for this page, for reference purposes)
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